Can I convert a US Topo from GeoPDF to GeoTIFF format?

Yes, it is possible to convert GeoPDF to GeoTIFF with either commercial or open source software:

1. Converting US Topo GeoPDF Layers to GeoTIFF (PDF document).

2. Information About Raster Conversion Scripts (web page).

3. The US Topo and Historical Topographic Map Users Guide (PDF document) contains some information about non-geospatial format conversions using graphics art software. 

As of April 2015, the National Geologic Map Database project's TopoView application serves GeoTIFF versions of maps in the  Historical Topographic Map Collection (HTMC). The GeoTIFF versions are not yet served through other applications, nor are they yet available for bulk delivery.

USGS has no plans to create standard GeoTIFF versions of US Topo maps, as the multi-layer nature of US Topo does not lend itself to a single, simple TIFF product.