Fish and aquatic habitats in Alaska support important commercial, sport, and subsistence fisheries and provide forage fish that support wildlife populations. The USGS Alaska Science Center conducts interdisciplinary research to inform local, state, federal, and international policy makers regarding conservation of fish, aquatic species, and their habitats. We work collaboratively with hydrologists, geologists and other biologists to study fish and aquatic systems in an ecosystem based framework. The goal of our current research effort is to improve our understanding of the biocomplexity, resilience, and function of aquatic ecosystems to better inform future predictions of fish and aquatic ecosystems as they respond to a changing environment.