Human-use pharmaceutical, pesticide, and wastewater indicator compounds were analyzed at the U.S. Geological Survey, National Water Quality Laboratory, Denver, Colorado, in wadeable streams in 4 Regional Stream Quality Assessments: Northeast (NESQA), Southeast (SESQA), Pacific Northwest (PNSQA) and California (CSQA). Multiple (with few exceptions) samplings occurred at each site, during base flow, between 2014 and 2017. Sites were located in the headwaters of perennial, wadeable streams in urban and agricultural watersheds. Site selection and methodology for each assessment can be found in Van Meter and others (2015), Sheibley and others (2015), Van Meter and others (2017), Coles and others (2016), Van Meter and others (2016), Journey and others (2015), and Van Meter and others (2014). Additional results for this study can be found in Bradley and others, 2020 and Mahler and others, 2020. See cross-reference section for full citation information.