Currently, maintaining appropriate flows to support biological integrity is difficult for larger riverine ecosystems. Climate change, through increased temperature, reduced rainfall, and increased rainfall intensity, is expected to reduce water availability and exacerbate the maintenance of ecological flows in the Arkansas-Red River basin. Understanding the nexus among climate change effects on streamflow, water quality, and stream ecology for watersheds in the Arkansas-Red River Basin can be achieved using currently existing science and technology. This nexus approach will strengthen adaptive-management strategies that focus on shared ecosystem conservation watershed targets. This approach will provide natural-resource managers operating over a variety of spatial scales with measureable relationships between biology and flow while building modeling, monitoring, and statistical capacity to support restoration, conservation, and management goals.