New Hepatitis B Virus Discovered in White Sucker (Catostomus commersonii) Completed
Collecting a liver tissue sample from a wild-caught white sucker
The first known hepatitis B virus to infect fish (white sucker; Catostomus commersonii) has been discovered by U.S. Geological Survey (USGS) scientists.
These findings, with the full genetic sequence of the virus, were published in the Journal of Virology. This newly discovered virus is in the family Hepadnaviridae, which include similar viruses in mammals and birds. This virus is unique from other known hepadnaviruses and likely represents a new genus. In mammals, including humans, these viruses are typically associated with liver diseases including fibrosis, cirrhosis, and cancer. Human hepatitis B virus has a specific protein that is associated with cancer induction, and this tumor-associated protein is not present in the new hepatitis B virus isolated from white suckers.
White suckers inhabit river systems in the Midwestern and Northeastern United States. As bottom-feeders, they are continuously exposed to contaminants in river sediments and are used as an indicator species in assessing the health of their aquatic environments. The incidence of liver tumors in these fish has been used as an indication of toxic contaminant exposure. It is not known if this newly identified virus is associated with tumors or liver disease in these fish, but it may be a risk factor.
This research was funded by the USGS Ecosystems Mission Area’s Environmental Health Program (Contaminant Biology and Toxic Substances Hydrology).
Below are other science projects associated with this project.
Immunomodulation Science Team
Fishing and Hunting Integrated Science Team
- Overview
The first known hepatitis B virus to infect fish (white sucker; Catostomus commersonii) has been discovered by U.S. Geological Survey (USGS) scientists.
Sources/Usage: Public Domain. View Media DetailsA USGS scientist collecting a liver tissue sample from a wild-caught white sucker (Catostomus commersonii) from a river in the Great Lakes area. Photo Credit: Patricia M. Mazik, USGS. These findings, with the full genetic sequence of the virus, were published in the Journal of Virology. This newly discovered virus is in the family Hepadnaviridae, which include similar viruses in mammals and birds. This virus is unique from other known hepadnaviruses and likely represents a new genus. In mammals, including humans, these viruses are typically associated with liver diseases including fibrosis, cirrhosis, and cancer. Human hepatitis B virus has a specific protein that is associated with cancer induction, and this tumor-associated protein is not present in the new hepatitis B virus isolated from white suckers.
White suckers inhabit river systems in the Midwestern and Northeastern United States. As bottom-feeders, they are continuously exposed to contaminants in river sediments and are used as an indicator species in assessing the health of their aquatic environments. The incidence of liver tumors in these fish has been used as an indication of toxic contaminant exposure. It is not known if this newly identified virus is associated with tumors or liver disease in these fish, but it may be a risk factor.
This research was funded by the USGS Ecosystems Mission Area’s Environmental Health Program (Contaminant Biology and Toxic Substances Hydrology).
Sources/Usage: Public Domain. View Media DetailsA white sucker (Catostomus commersonii). Photo Credit: Fairfax County Government, Virginia. - Science
Below are other science projects associated with this project.
Immunomodulation Science Team
The Immunomodulation Integrated Science Team focuses on contaminant and pathogen exposures in the environment that might influence the immune systems of wildlife and the connection to their shared environment with humans. In collaboration with public-health officials, the Team also addresses potential human-health risks stemming from similar exposures. If actual risks are identified, this Team...Fishing and Hunting Integrated Science Team
The Fishing and Hunting integrated science team focuses on contaminant and pathogen exposures in the environment that could impact the presence and vitality of fish and wildlife populations that drive commercial, recreational and subsistence activities such as hunting and fishing. If actual risks are identified this project will inform how to economically and effectively minimize risk by providing... - Publications
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