Organic Geochemistry Research Core Technology Team Active
Pressurized fluid extractor used to extract organic compounds
Time-of-flight mass spectrometer used for the analysis of pesticides
New (2018) instrument laboratory at the OGRL
New (2018) sample processing laboratory at the OGRL
About the Research
The Organic Geochemistry Research Laboratory Core Technology Team (CTT) as part of the Environmental Health Program works to develop targeted and non-targeted analytical methods for the identification and quantitation of chemicals that can impact the health of humans and other organisms, and uses bioassays to screen for receptor inhibition.
The Organic Geochemistry Research Laboratory (OGRL) CTT focuses on contributing new knowledge on the distribution, fate, and transport of new and understudied organic compounds.
Compounds and contaminants studied by the CTT are suspected of causing undesired effects on animal, human, and ecosystem health. Routine methods of analysis include antibiotics, artificial sweeteners, endocrine disrupting hormones, mycotoxins, and pesticides in surface water, wastewater, drinking water, manures, soils, and sediments. Capabilities include sampling logistics, sample preparation techniques (ASE, EDGE, SPE, and extractions for biological assays), and trace-level targeted analysis (LC-MS/MS). The OGRL CTT is continuously expanding capabilities and offers custom method development for new compounds and matrices, and as such is able to address emerging issues like microplastics and tire wear particles.
Key Analytical Capabilities
- Antibiotics
- Artificial Sweeteners
- Hormones and Endocrine Disrupting Compounds
- Mycotoxins
- Pharmaceuticals
- Pesticides (glyphosate, aminomethylphosphonic acid, glufosinate, atrazine)
- Tire Related Chemicals
Key Instrumentation
- Sample preparation techniques (ASE, EDGE, SPE, and extractions for biological assays)
- Targeted analysis LC-MS/MS
- Three bioinert liquid chromatography/triple quadrupole mass spectrometers
- Two bioinert liquid chromatography/accurate mass spectrometers to understand complexity of chemical mixtures and for identification of unknown chemicals
- Automated bioassay plate reader and Fourier Transform Infrared spectrophotometer for measuring receptor inhibition and chemical screening
- Solid phase and pressurized fluid extraction for working with a variety of liquid and solid samples
† Hypertext links to non-USGS products and services; and the use of trade names, trademarks, company names, or other references to non-USGS products and services are provided for information only and do not constitute endorsement or warranty by the U.S. Geological Survey (USGS), U.S. Department of the Interior, or U.S. Government.
Environmental Health Integrated Science Team Collaborators
-
Food Resources Lifecycle Integrated Science Team
The team studies the movement of toxicants and pathogens that could originate from the growing, raising, and processing/manufacturing of plant and animal products through the environment where exposure can occur. This information is used to understand if there are adverse effects upon exposure and to develop decision tools to protect health.Energy Integrated Science Team
The Energy Lifecycle Integrated Science Team focuses on the potential for contaminant exposures in the environment that might originate from energy resource activities including, extraction, production, transportation, storage, extraction, waste management and restoration. Perceived health risks to humans and other organisms will be distinguished from actual risks, if any. If actual risks are...Drinking Water and Wastewater Infrastructure Science Team
The team studies toxicants and pathogens in water resources from their sources, through watersheds, aquifers, and infrastructure to human and wildlife exposures. That information is used to develop decision tools that protect human and wildlife health.
Science activities related to the Organic Geochemistry Research Laboratory Core Technology Team can be found below.
6PPD-Quinone
Data related to the Organic Geochemistry Research Laboratory Core Technology Team can be found below.
State-Wide Reconnaissance of Per- and Polyfluoroalkyl Substances, N-(1,3-Dimethylbutyl)-N-phenyl-p-phenylenediamine (6PPD), and 6PPD-Quinone in Iowa Streams, 2022-2023
Antibiotic and Antibiotic Resistance Signatures in Iowa Streams, 2019
High-Resolution Mass Spectrometry Data for Wastewater Samples Collected at an on-Site Separator and Storage Tank at the Marcellus Shale Energy and Environment Laboratory (MSEEL) 2015-2019, Morgantown Industrial Park (MIP), West Virginia
Results from U.S. Geological Survey Environmental Health Food Resources Lifecycle Integrated Science Team, Graton Pesticides (GRAPE) Study, in Graton, California, April–May 2021
Mortality, morphology, and water chemistry for 6PPD-quinone exposed coho embryos
Assessing cell line models for species differences in 6PPD-quinone sensitivity
Water-quality results from a wastewater reuse study: Inorganic and organic compositions of wastewater effluent and select urban and agricultural water types during rain-induced runoff, Chickasha, Oklahoma, 2018-2019
Assessment of Endocrine Disruption in the Shenandoah River Watershed - Chemical and Biological Data from Mobile Laboratory Fish Exposures and Other Experiments Conducted during 2014, 2015, and 2016
Concentrations of glyphosate and atrazine compounds in 100 Midwest United States streams in 2013
Scientific publications related to the Organic Geochemistry Research Laboratory Core Technology Team can be found below.
Simultaneous stream assessment of antibiotics, bacteria, antibiotic resistant bacteria, and antibiotic resistant genes in an agricultural region of the United States
Tire-derived transformation product 6PPD-quinone induces mortality and transcriptionally disrupts vascular permeability pathways in developing coho salmon
Establishing an in vitro model to assess the toxicity of 6PPD-quinone and other tire wear transformation products
Juxtaposition of intensive agriculture, vulnerable aquifers, and mixed chemical/microbial exposures in private-well tapwater in northeast Iowa
Contaminant exposure and transport from three potential reuse waters within a single watershed
Transcriptome signatures of wastewater effluent exposure in larval zebrafish vary with seasonal mixture composition in an effluent-dominated stream
Food, beverage, and feedstock processing facility wastewater: A unique and underappreciated source of contaminants to U.S. streams
Pilot-scale expanded assessment of inorganic and organic tapwater exposures and predicted effects in Puerto Rico, USA
Mixed organic and inorganic tapwater exposures and potential effects in greater Chicago area, USA
Polyoxyethylene tallow amine, a glyphosate formulation adjuvant: Soil adsorption characteristics, degradation profile, and occurrence on selected soils from agricultural fields in Iowa, Illinois, Indiana, Kansas, Mississippi, and Missouri
Characterization of polyoxyethylene tallow amine surfactants in technical mixtures and glyphosate formulations using ultra-high performance liquid chromatography and triple quadrupole mass spectrometry
Eleven-year trend in acetanilide pesticide degradates in the Iowa River, Iowa
News items related to the Organic Geochemistry Research Laboratory Core Technology Team can be found below.
Connect with members of the Organic Geochemistry Research Laboratory Core Technology Team below.
Michaelah C Wilson
Environmental Chemist
Environmental Chemist
External partners that the Organic Geochemistry Research Laboratory Core Technology Team collaborates with are linked below.
- Overview
About the Research
The Organic Geochemistry Research Laboratory Core Technology Team (CTT) as part of the Environmental Health Program works to develop targeted and non-targeted analytical methods for the identification and quantitation of chemicals that can impact the health of humans and other organisms, and uses bioassays to screen for receptor inhibition.
The Organic Geochemistry Research Laboratory (OGRL) CTT focuses on contributing new knowledge on the distribution, fate, and transport of new and understudied organic compounds.
Compounds and contaminants studied by the CTT are suspected of causing undesired effects on animal, human, and ecosystem health. Routine methods of analysis include antibiotics, artificial sweeteners, endocrine disrupting hormones, mycotoxins, and pesticides in surface water, wastewater, drinking water, manures, soils, and sediments. Capabilities include sampling logistics, sample preparation techniques (ASE, EDGE, SPE, and extractions for biological assays), and trace-level targeted analysis (LC-MS/MS). The OGRL CTT is continuously expanding capabilities and offers custom method development for new compounds and matrices, and as such is able to address emerging issues like microplastics and tire wear particles.
Key Analytical Capabilities
- Antibiotics
- Artificial Sweeteners
- Hormones and Endocrine Disrupting Compounds
- Mycotoxins
- Pharmaceuticals
- Pesticides (glyphosate, aminomethylphosphonic acid, glufosinate, atrazine)
- Tire Related Chemicals
Key Instrumentation
- Sample preparation techniques (ASE, EDGE, SPE, and extractions for biological assays)
- Targeted analysis LC-MS/MS
- Three bioinert liquid chromatography/triple quadrupole mass spectrometers
- Two bioinert liquid chromatography/accurate mass spectrometers to understand complexity of chemical mixtures and for identification of unknown chemicals
- Automated bioassay plate reader and Fourier Transform Infrared spectrophotometer for measuring receptor inhibition and chemical screening
- Solid phase and pressurized fluid extraction for working with a variety of liquid and solid samples
† Hypertext links to non-USGS products and services; and the use of trade names, trademarks, company names, or other references to non-USGS products and services are provided for information only and do not constitute endorsement or warranty by the U.S. Geological Survey (USGS), U.S. Department of the Interior, or U.S. Government.
Environmental Health Integrated Science Team Collaborators-
Food Resources Lifecycle Integrated Science Team
The team studies the movement of toxicants and pathogens that could originate from the growing, raising, and processing/manufacturing of plant and animal products through the environment where exposure can occur. This information is used to understand if there are adverse effects upon exposure and to develop decision tools to protect health.Energy Integrated Science Team
The Energy Lifecycle Integrated Science Team focuses on the potential for contaminant exposures in the environment that might originate from energy resource activities including, extraction, production, transportation, storage, extraction, waste management and restoration. Perceived health risks to humans and other organisms will be distinguished from actual risks, if any. If actual risks are...Drinking Water and Wastewater Infrastructure Science Team
The team studies toxicants and pathogens in water resources from their sources, through watersheds, aquifers, and infrastructure to human and wildlife exposures. That information is used to develop decision tools that protect human and wildlife health.
- Science
Science activities related to the Organic Geochemistry Research Laboratory Core Technology Team can be found below.
6PPD-Quinone
6PPD-Q is a compound used to make tires more durable and is also linked to toxicity for Coho Salmon and other aquatic species. - Data
Data related to the Organic Geochemistry Research Laboratory Core Technology Team can be found below.
State-Wide Reconnaissance of Per- and Polyfluoroalkyl Substances, N-(1,3-Dimethylbutyl)-N-phenyl-p-phenylenediamine (6PPD), and 6PPD-Quinone in Iowa Streams, 2022-2023
Water-quality samples were collected at 49 surface water sites covering a range of land uses across the state of Iowa starting the summer of 2022 and continuing into the spring of 2023 by staff from the U.S. Geological Survey Central Midwest Water Science Center. Samples were submitted to the National Water Quality Laboratory in Denver, Colorado, and were analyzed for 32 per- and polyfluoroalkyl sAntibiotic and Antibiotic Resistance Signatures in Iowa Streams, 2019
Chemical and microbiological results, quality assurance and quality control, site location, and method information for surface water, bed sediment, and wastewater effluent collected from 34 stream locations across Iowa (United States). Environmental samples were analyzed for a suite of 29 antibiotics, plated on selective media for 15 types of bacteria growth, and DNA was extracted from culture groHigh-Resolution Mass Spectrometry Data for Wastewater Samples Collected at an on-Site Separator and Storage Tank at the Marcellus Shale Energy and Environment Laboratory (MSEEL) 2015-2019, Morgantown Industrial Park (MIP), West Virginia
The Marcellus Shale Energy and Environment Laboratory (MSEEL) is part of the Northeast Natural Energy LLC (NNE) production facility on the Monongahela River in Monongalia County, West Virginia, USA. Natural gas extraction in the area creates large volumes of wastewater that may contain chemical compounds that pose risks to humans, animals, and the environment. The U. S. Geological Survey (USGS) haResults from U.S. Geological Survey Environmental Health Food Resources Lifecycle Integrated Science Team, Graton Pesticides (GRAPE) Study, in Graton, California, April–May 2021
In the spring of 2021, six households with private wells were selected throughout Graton, California, based on proximity to agriculture (within one mile of agriculture), well depth (i.e., less than 150 feet in depth), and well type (i.e., dug versus drilled). Silicone bands were deployed for 30 days at outdoor locations at each household to passively sample pesticides in ambient air. On May 3, 202Mortality, morphology, and water chemistry for 6PPD-quinone exposed coho embryos
Understanding evolutionary processes that drive population dynamics is critical in ecology. Measuring the performance-density relationship in long-lived mammalian species demands long-term data, limiting the ability to observe such mechanisms. We tested density-dependent (intrinsic) and density-independent (extrinsic) drivers of body composition of grizzly bears (Ursus arctos) in the Greater YelloAssessing cell line models for species differences in 6PPD-quinone sensitivity
Coho salmon have been shown to be highly sensitive to the tire transformation chemical 6PPD-quinone, with concentrations contained in stormwater sufficient to induce mortality in up to 90% of the entire fall coho run. Other salmonid species (chinook, sockeye, chum) are much less sensitive to 6PPD-quinone induced mortality. This data examines the varying species sensitivities across salmoids usingWater-quality results from a wastewater reuse study: Inorganic and organic compositions of wastewater effluent and select urban and agricultural water types during rain-induced runoff, Chickasha, Oklahoma, 2018-2019
Oklahoma State University South-Central Research Station (SCRS) was used to conduct research to understand the chemical composition of various water types and their potential environmental and human health effects. The study area provided the opportunity to study five water types: (1) receiving surface water (Washita River), (2) urban stormwater, (3) wastewater treatment plant effluent used for irAssessment of Endocrine Disruption in the Shenandoah River Watershed - Chemical and Biological Data from Mobile Laboratory Fish Exposures and Other Experiments Conducted during 2014, 2015, and 2016
This data release presents chemical and biological results from investigations of water quality, fish endocrine disruption, and emergent insects in the Shenandoah River Watershed (Virginia and West Virginia, USA) conducted during 2014, 2015, and 2016. Multiple sampling campaigns were conducted at sites located throughout the Shenandoah River Watershed (Table 1). The complex inorganic and organic cConcentrations of glyphosate and atrazine compounds in 100 Midwest United States streams in 2013
Glyphosate and atrazine are the most intensively used herbicides in the United States. Temporal patterns in glyphosate and atrazine concentrations were measured weekly by the USGS during the 2013 growing season in 100 small streams in the Midwestern United States. Concentrations also were measured every 2 days at a subset of 8 of the sites, all located in Missouri. Glyphosate was detected more fr - Publications
Scientific publications related to the Organic Geochemistry Research Laboratory Core Technology Team can be found below.
Filter Total Items: 19Simultaneous stream assessment of antibiotics, bacteria, antibiotic resistant bacteria, and antibiotic resistant genes in an agricultural region of the United States
Antimicrobial resistance is now recognized as a leading global threat to human health. Nevertheless, there currently is a limited understanding of the environment's role in the spread of AMR and antibiotic resistant genes (ARG). In 2019, the U.S. Geological Survey conducted the first statewide assessment of antibiotic resistant bacteria (ARB) and ARGs in surface water and bed sediment collected frAuthorsCarrie E Givens, Dana W. Kolpin, Laura E. Hubbard, Shannon M. Meppelink, David M. Cwiertny, Darrin A. Thompson, Rachael F. Lane, Michaelah C. WilsonTire-derived transformation product 6PPD-quinone induces mortality and transcriptionally disrupts vascular permeability pathways in developing coho salmon
Urban stormwater runoff frequently contains the car tire transformation product 6PPD-quinone, which is highly toxic to juvenile and adult coho salmon (Onchorychus kisutch). However, it is currently unclear if embryonic stages are impacted. We addressed this by exposing developing coho salmon embryos starting at the eyed stage to three concentrations of 6PPD-quinone twice weekly until hatch. ImpactAuthorsJustin Blaine Greer, Ellie Maureen Dalsky, Rachael F. Lane, John HansenEstablishing an in vitro model to assess the toxicity of 6PPD-quinone and other tire wear transformation products
The tire wear transformation product 6PPD-quinone (6PPDQ) has been implicated as the causative factor for broad scale mortality events for coho salmon in the Pacific Northwest. Highly variable sensitivity to 6PPDQ in closely related salmonids complicates efforts to evaluate the broader toxicological impacts to aquatic ecosystems. Our goals were to (1) validate the large range of in vivo species seAuthorsJustin Blaine Greer, Ellie Maureen Dalsky, Rachael F. Lane, John HansenJuxtaposition of intensive agriculture, vulnerable aquifers, and mixed chemical/microbial exposures in private-well tapwater in northeast Iowa
In the United States and globally, contaminant exposure in unregulated private-well point-of-use tapwater (TW) is a recognized public-health data gap and an obstacle to both risk-management and homeowner decision making. To help address the lack of data on broad contaminant exposures in private-well TW from hydrologically-vulnerable (alluvial, karst) aquifers in agriculturally-intensive landscapesAuthorsPaul M. Bradley, Dana W. Kolpin, Darrin A. Thompson, Kristin M. Romanok, Kelly L. Smalling, Sara E. Breitmeyer, Mary C. Cardon, David M. Cwiertny, Nicola Evans, R. William Field, Michael J. Focazio, Laura E. Beane Freeman, Carrie E Givens, James L. Gray, Gordon L. Hager, Michelle Hladik, Jonathan N. Hoffman, Rena R. Jones, Leslie K. Kanagy, Rachael F. Lane, R. Blaine McCleskey, Danielle Medgyesi, Elizabeth Medlock-Kakaley, Shannon M. Meppelink, Michael T. Meyer, Diana A. Stavreva, Mary H. WardContaminant exposure and transport from three potential reuse waters within a single watershed
Global demand for safe and sustainable water supplies necessitates a better understanding of contaminant exposures in potential reuse waters. In this study, we compared exposures and load contributions to surface water from the discharge of three reuse waters (wastewater effluent, urban stormwater, and agricultural runoff). Results document substantial and varying organic-chemical contribution toAuthorsJason R. Masoner, Dana W. Kolpin, Isabelle M. Cozzarelli, Paul M. Bradley, Brian Arnall, Kenneth J. Forshay, James L. Gray, Justin F. Groves, Michelle Hladik, Laura E. Hubbard, Luke R. Iwanowicz, Jeanne B. Jaeschke, Rachael F. Lane, R. Blaine McCleskey, Bridgette F. Polite, David A. Roth, Michael Pettijohn, Michaelah C. WilsonByWater Resources Mission Area, Environmental Health Program, Eastern Ecological Science Center, Colorado Water Science Center, California Water Science Center, Central Midwest Water Science Center, Geology, Energy & Minerals Science Center, Kansas Water Science Center, Oklahoma-Texas Water Science Center, South Atlantic Water Science Center (SAWSC), Upper Midwest Water Science Center, Reston Biogeochemical Processes in Groundwater LaboratoryTranscriptome signatures of wastewater effluent exposure in larval zebrafish vary with seasonal mixture composition in an effluent-dominated stream
Wastewater treatment plant (WWTP) effluent-dominated streams provide critical habitat for aquatic and terrestrial organisms but also continually expose them to complex mixtures of pharmaceuticals that can potentially impair growth, behavior, and reproduction. Currently, few biomarkers are available that relate to pharmaceutical-specific mechanisms of action. In the experiment reported in this papeAuthorsEmma B. Meade, Luke R. Iwanowicz, Nicklaus Neureuther, Gregory H. LeFevre, Dana W. Kolpin, Hui Zhi, Shannon M. Meppelink, Rachael F. Lane, Angela Schmoldt, Aurash Mohaimani, Olaf Mueller, Rebecca D. KlaperFood, beverage, and feedstock processing facility wastewater: A unique and underappreciated source of contaminants to U.S. streams
Process wastewaters from food, beverage, and feedstock facilities, although regulated, are an under-investigated environmental contaminant source. Food process wastewaters (FPWWs) from 23 facilities in 17 U.S. states were sampled and documented for a plethora of chemical and microbial contaminants. Of the 576 analyzed organics, 184 (32%) were detected at least once, with concentrations as large asAuthorsLaura E. Hubbard, Dana W. Kolpin, Carrie E Givens, Bradley D. Blackwell, Paul M. Bradley, James L. Gray, Rachael F. Lane, Jason R. Masoner, R. Blaine McCleskey, Kristin M. Romanok, Mark W. Sandstrom, Kelly L. Smalling, Daniel L. VilleneuveByEcosystems Mission Area, Water Resources Mission Area, Contaminant Biology, Environmental Health Program, Toxic Substances Hydrology, Central Midwest Water Science Center, Kansas Water Science Center, New Jersey Water Science Center, Pennsylvania Water Science Center, South Atlantic Water Science Center (SAWSC), Upper Midwest Water Science Center, National Water Quality LaboratoryPilot-scale expanded assessment of inorganic and organic tapwater exposures and predicted effects in Puerto Rico, USA
A pilot-scale expanded target assessment of mixtures of inorganic and organic contaminants in point-of-consumption drinking water (tapwater, TW) was conducted in Puerto Rico (PR) to continue to inform TW exposures and corresponding estimations of cumulative human-health risks across the US. In August 2018, a spatial synoptic pilot assessment of than 524 organic, 37 inorganic, and select microbioloAuthorsPaul M. Bradley, Ingrid Y. Padilla, Kristin M. Romanok, Kelly Smalling, Michael J. Focazio, Sara E. Breitmeyer, Mary C. Cardon, Justin M. Conley, Nicola Evans, Carrie E Givens, James L. Gray, L. Earl Gray, Phillip C. Hartig, Michelle Hladik, Christopher P. Higgins, Luke R. Iwanowicz, Rachael F. Lane, Keith Loftin, R. Blaine McCleskey, Carrie A. McDonough, Elizabeth Medlock-Kakaley, Shannon M. Meppelink, Christopher P. Weis, Vickie S. WilsonMixed organic and inorganic tapwater exposures and potential effects in greater Chicago area, USA
Safe drinking water at the point of use (tapwater, TW) is a public-health priority. TW exposures and potential human-health concerns of 540 organics and 35 inorganics were assessed in 45 Chicago area United States (US) homes in 2017. No US Environmental Protection Agency (EPA) enforceable Maximum Contaminant Level(s) (MCL) were exceeded in any residential or water treatment plant (WTP) pre-distribAuthorsPaul Bradley, Maria Argos, Dana W. Kolpin, Shannon M. Meppelink, Kristin M. Romanok, Kelly L. Smalling, Michael J. Focazio, Joshua M. Allen, Julie E. Dietze, Michael J. Devito, Ariel Donovan, Nicola Evans, Carrie E. Givens, James L. Gray, Christopher P. Higgins, Michelle Hladik, Luke Iwanowicz, Celeste A. Journey, Rachael F. Lane, Zachary Laughrey, Keith A. Loftin, R. Blaine McCleskey, Carrie A. McDonough, Elizabeth K Medlock Kakaley, Michael T. Meyer, Andrea Holthouse-Putz, Susan D Richardson, Alan Stark, Christopher P. Weis, Vickie S. Wilson, Abderrahman ZehraouiPolyoxyethylene tallow amine, a glyphosate formulation adjuvant: Soil adsorption characteristics, degradation profile, and occurrence on selected soils from agricultural fields in Iowa, Illinois, Indiana, Kansas, Mississippi, and Missouri
Polyoxyethylene tallow amine (POEA) is an inert ingredient added to formulations of glyphosate, the most widely applied agricultural herbicide. POEA has been shown to have toxic effects to some aquatic organisms making the potential transport of POEA from the application site into the environment an important concern. This study characterized the adsorption of POEA to soils and assessed its occurrAuthorsDaniel L. Tush, Michael T. MeyerCharacterization of polyoxyethylene tallow amine surfactants in technical mixtures and glyphosate formulations using ultra-high performance liquid chromatography and triple quadrupole mass spectrometry
Little is known about the occurrence, fate, and effects of the ancillary additives in pesticide formulations. Polyoxyethylene tallow amine (POEA) is a non-ionic surfactant used in many glyphosate formulations, a widely applied herbicide both in agricultural and urban environments. POEA has not been previously well characterized, but has been shown to be toxic to various aquatic organisms. CharacteAuthorsDaniel Tush, Keith A. Loftin, Michael T. MeyerEleven-year trend in acetanilide pesticide degradates in the Iowa River, Iowa
Trends in concentration and loads of acetochlor, alachlor, and metolachlor and their ethanasulfonic (ESA) and oxanilic (OXA) acid degradates were studied from 1996 through 2006 in the main stem of the Iowa River, Iowa and in the South Fork Iowa River, a small tributary near the headwaters of the Iowa River. Concentration trends were determined using the parametric regression model SEAWAVE-Q, whichAuthorsStephen J. Kalkhoff, Aldo V. Vecchia, Paul D. Capel, Michael T. Meyer - News
News items related to the Organic Geochemistry Research Laboratory Core Technology Team can be found below.
- Connect
Connect with members of the Organic Geochemistry Research Laboratory Core Technology Team below.
Michaelah C Wilson
Environmental ChemistEnvironmental ChemistEmailPhone - Partners
External partners that the Organic Geochemistry Research Laboratory Core Technology Team collaborates with are linked below.