Science and Products
Selected Pharmaceuticals Not Likely to Persist in Wild Fish: Results of Uptake and Elimination Testing
Laboratory study shows that both uptake and elimination of selected pharmaceuticals within bluegill tissues is rapid indicating that persistence in bluegills in the environment is likely to be low except in those fish that reside downstream from a consistent, substantial, contaminant source.
Pharmaceutical manufacturing facility discharges can substantially increase the pharmaceutical load to U.S. wastewaters
Discharges from pharmaceutical manufacturing facilities (PMFs) previously have been identified as important sources of pharmaceuticals to the environment. Yet few studies are available to establish the influence of PMFs on the pharmaceutical source contribution to wastewater treatment plants (WWTPs) and waterways at the national scale....Scott, Tia-Marie; Phillips, Patrick J.; Kolpin, Dana W.; Colella, Kaitlyn M.; Furlong, Edward T.; Foreman, William T.; Gray, James L.
Modeled de facto reuse and contaminants of emerging concern in drinking water source waters
De facto reuse is the percentage of drinking water treatment plant (DWTP) intake potentially composed of effluent discharged from upstream wastewater treatment plants (WWTPs). Results from grab samples and a De Facto Reuse in our Nation's Consumable Supply (DRINCS) geospatial watershed model were used to quantify contaminants of emerging concern (...Nguyen, Thuy; Westerhoff, Paul; Furlong, Edward T.; Kolpin, Dana W.; Batt, Angela L.; Mash, Heath E.; Schenck, Kathleen M.; Boone, J. Scott; Rice, Jacelyn; Glassmeyer, Susan T.
Contaminants of emerging concern presence and adverse effects in fish: A case study in the Laurentian Great Lakes
The Laurentian Great Lakes are a valuable natural resource that is affected by contaminants of emerging concern (CECs), including sex steroid hormones, personal care products, pharmaceuticals, industrial chemicals, and new generation pesticides. However, little is known about the fate and biological effects of CECs in tributaries to the Great...Jorgenson, Zachary G.; Thomas, Linnea M.; Elliott, Sarah M.; Cavallin, Jenna E.; Randolph, Eric C.; Choy, Steven J.; Alvarez, David; Banda, Jo A.; Gefell, Daniel J.; Lee, Kathy E.; Furlong, Edward T.; Schoenfuss, Heiko L.
Estimating virus occurrence using Bayesian modeling in multiple drinking water systems of the United States
Drinking water treatment plants rely on purification of contaminated source waters to provide communities with potable water. One group of possible contaminants are enteric viruses. Measurement of viral quantities in environmental water systems are often performed using polymerase chain reaction (PCR) or quantitative PCR (qPCR). However, true...Varughese, Eunice A.; Brinkman, Nichole E; Anneken, Emily M; Cashdollar, Jennifer S; Fout, G. Shay; Furlong, Edward T.; Kolpin, Dana W.; Glassmeyer, Susan T.; Keely, Scott P
Are exposure predictions, used for the prioritization of pharmaceuticals in the environment, fit for purpose?
Prioritization methodologies are often used for identifying those pharmaceuticals that pose the greatest risk to the natural environment and to focus laboratory testing or environmental monitoring toward pharmaceuticals of greatest concern. Risk-based prioritization approaches, employing models to derive exposure concentrations, are commonly used...Burns, Emily E.; Thomas-Oates, Jane; Kolpin, Dana W.; Furlong, Edward T.; Boxall, Alistair B.A.
Uptake and disposition of select pharmaceuticals by bluegill exposed at constant concentrations in a flow-through aquatic exposure system
The increasing use of pharmaceuticals has led to their subsequent input into and release from wastewater treatment plants, with corresponding discharge into surface waters that may subsequently exert adverse effects upon aquatic organisms. Although the distribution of pharmaceuticals in surface water has been extensively studied, the details of...Zhao, Jian-Liang; Furlong, Edward T.; Schoenfuss, Heiko L.; Kolpin, Dana W.; Bird, Kyle L.; Feifarek, David J.; Schwab, Eric A.; Ying, Guang-Guo
Expanded target-chemical analysis reveals extensive mixed-organic-contaminant exposure in USA streams
Surface water from 38 streams nationwide was assessed using 14 target-organic methods (719 compounds). Designed-bioactive anthropogenic contaminants (biocides, pharmaceuticals) comprised 57% of 406 organics detected at least once. The 10 most-frequently detected anthropogenic-organics included eight pesticides (desulfinylfipronil, AMPA,...Bradley, Paul M.; Journey, Celeste A.; Romanok, Kristin; Barber, Larry B.; Buxton, Herbert T.; Foreman, William T.; Furlong, Edward T.; Glassmeyer, Susan T.; Hladik, Michelle L.; Iwanowicz, Luke R. ; Jones, Daniel K.; Kolpin, Dana W.; Kuivila, Kathryn M. ; Loftin, Keith A.; Mills, Marc A.; Meyer, Michael T.; Orlando, James L. ; Reilly, Timothy J.; Smalling, Kelly L. ; Villeneuve, Daniel L.
Methods used to characterize the chemical composition and biological activity of environmental waters throughout the United States, 2012-14
A vast array of chemical compounds are in wide commercial use in the United States, and the potential ecological and human-health effect of exposure to chemical mixtures has been identified as a high priority in environment health science. Awareness of the potential effects of low-level chemical exposures is rising. The U.S. Geological Survey, in...Romanok, Kristin M. ; Reilly, Timothy J.; Barber, Larry B.; Boone, J. Scott; Buxton, Herbert T.; Foreman, William T. ; Furlong, Edward T.; Hladik, Michelle; Iwanowicz, Luke R. ; Journey, Celeste A.; Kolpin, Dana W.; Kuivila, Kathryn ; Loftin, Keith A.; Mills, Marc A.; Meyer, Michael T.; Orlando, James L. ; Smalling, Kelly L. ; Villeneuve, Daniel L.; Bradley, Paul M.
Nationwide reconnaissance of contaminants of emerging concern in source and treated drinking waters of the United States
When chemical or microbial contaminants are assessed for potential effect or possible regulation in ambient and drinking waters, a critical first step is determining if the contaminants occur and if they are at concentrations that may cause human or ecological health concerns. To this end, source and treated drinking water samples from 29 drinking...Glassmeyer, Susan T.; Furlong, Edward T.; Kolpin, Dana W.; Batt, Angela L.; Benson, Robert; Boone, J. Scott; Conerly, Octavia D.; Donohue, Maura J.; King, Dawn N.; Kostich, Mitchell S.; Mash, Heath E.; Pfaller, Stacy; Schenck, Kathleen M.; Simmons, Jane Ellen; Varughese, Eunice A.; Vesper, Stephen J.; Villegas, Eric N.; Wilson, Vickie S.
Aquatic concentrations of chemical analytes compared to ecotoxicity estimates
We describe screening level estimates of potential aquatic toxicity posed by 227 chemical analytes that were measured in 25 ambient water samples collected as part of a joint USGS/USEPA drinking water plant study. Measured concentrations were compared to biological effect concentration (EC) estimates, including USEPA aquatic life criteria,...Kostich, Mitchell S.; Flick, Robert W. ; Angela L. Batt; Mash, Heath E.; Boone, J. Scott; Furlong, Edward T.; Kolpin, Dana W.; Glassmeyer, Susan T.
Comparison of in vitro estrogenic activity and estrogen concentrations insource and treated waters from 25 U.S. drinking water treatment plants
In vitro bioassays have been successfully used to screen for estrogenic activity in wastewater and surface water, however, few have been applied to treated drinking water. Here, extracts of source and treated water samples were assayed for estrogenic activity using T47D-KBluc cells and analyzed by liquid chromatography-Fourier transform mass...Conley, Justin M.; Evans, Nicola; Mash, Heath; Rosenblum, Laura; Schenck, Kathleen; Glassmeyer, Susan; Furlong, Edward T.; Kolpin, Dana W.; Wilson, Vickie S.
Human health screening and public health significance of contaminants of emerging concern detected in public water supplies
The source water and treated drinking water from twenty five drinking water treatment plants (DWTPs) across the United States were sampled in 2010–2012. Samples were analyzed for 247 contaminants using 15 chemical and microbiological methods. Most of these contaminants are not regulated currently either in drinking water or in discharges to...Benson, Robert; Conerly, Octavia D.; Sander, William; Batt, Angela L.; Boone, J. Scott; Furlong, Edward T.; Glassmeyer, Susan T.; Kolpin, Dana W.; Mash, Heath