Jason Berninger, Ph.D. (Former Employee)
Science and Products
Predictive analysis using chemical-gene interaction networks consistent with observed endocrine activity and mutagenicity of U.S. streams
In a recent U.S. Geological Survey/U.S. Environmental Protection Agency study assessing >700 organic compounds in 38 streams, in vitro assays indicated generally low estrogen, androgen, and glucocorticoid receptor activities, but identified 13 surface waters with 17β estradiol equivalent (E2Eq) activities greater than the 1 ng/L level of...
Berninger, Jason P.; DeMarini, David M.; Warren, Sarah H.; Simmons, Jane Ellen; Wilson, Vickie S.; Conley, Justin M.; Armstrong, Mikayla D.; Kolpin, Dana W.; Kuivila, Kathryn; Reilly, Timothy J.; Romanok, Kristin M.; Villeneuve, Daniel L.; Bradley, Paul M.; Iwanowicz, Luke R.Polychlorinated biphenyl tissue‐concentration thresholds for survival, growth, and reproduction in fish
Polychlorinated biphenyls (PCBs) have left a legacy of environmental contamination. Even though they were banned from production and active use in the 1970s, they persist in the environment and still have the potential to impact aquatic life. Our objective was to identify data from controlled laboratory studies of PCB‐related adverse effects in...
Berninger, Jason P.; Tillitt, Donald E.Mixed-chemical exposure and predicted effects potential in wadeable southeastern USA streams
Complex chemical mixtures have been widely reported in larger streams but relatively little work has been done to characterize them and assess their potential effects in headwaterstreams. In 2014, the United States Geological Survey (USGS) sampled 54 Piedmont streams over ten weeks and measured 475 unique organic compounds...
Bradley, Paul M.; Journey, Celeste A.; Berninger, Jason P.; Button, Daniel T.; Clark, Jimmy M.; Corsi, Steven R.; DeCicco, Laura A.; Hopkins, Kristina G.; Huffman, Bradley J.; Nakagaki, Naomi; Norman, Julia E.; Nowell, Lisa H.; Qi, Sharon L.; Van Metre, Peter C.; Waite, Ian R.Linking field-based metabolomics and chemical analyses to prioritize contaminants of emerging concern in the Great Lakes basin
The ability to focus on the most biologically relevant contaminants affecting aquatic ecosystems can be challenging because toxicity-assessment programs have not kept pace with the growing number of contaminants requiring testing. Because it has proven effective at assessing the biological impacts of potentially toxic contaminants, profiling of...
Davis, John M.; Ekman, Drew R.; Teng, Quincy; Ankley, Gerald T.; Berninger, Jason P.; Cavallin, Jenna E.; Jensen, Kathleen M.; Kahl, Michael D.; Schroeder, Anthony L.; Villeneuve, Daniel L.; Jorgenson, Zachary G.; Lee, Kathy; Collette, Timothy W.Pathway-based approaches for assessment of real-time exposure to an estrogenic wastewater treatment plant effluent on fathead minnow reproduction
Wastewater treatment plant (WWTP) effluents are known contributors of chemical mixtures into the environment. Of particular concern are endocrine-disrupting compounds, such as estrogens, which can affect the hypothalamic-pituitary-gonadal axis function in exposed organisms. The present study examined reproductive effects in fathead minnows exposed...
Cavallin, Jenna E.; Jensen, Kathleen M.; Kahl, Michael D.; Villeneuve, Daniel L.; Lee, Kathy; Schroeder, Anthony L.; Mayasich, Joe; Eid, Evan P.; Nelson, Krysta R.; Milsk, Rebecca Y.; Blackwell, Brett R.; Berninger, Jason P.; LaLone, Carlie A.; Blanskma, Chad; Jicha, Terri M.; Elonen, Colleen M.; Johnson, Rodney C.; Ankley, Gerald T.