Tonie Rocke
Tonie Rocke is a Research Epidemiologist at the National Wildlife Health Center.
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Differential plague susceptibility in species and populations of prairie dogs
Laboratory trials conducted over the past decade at U.S. Geological Survey National Wildlife Health Center indicate that wild populations of prairie dogs (Cynomys spp.) display different degrees of susceptibility to experimental challenge with fully virulent Yersinia pestis, the causative agent of plague. We evaluated patterns in prairie dog susceptibility to plague to determine whether the histor
Authors
Robin E. Russell, Daniel W. Tripp, Tonie E. Rocke
Rabies outbreak in captive big brown bats (Eptesicus fuscus) used in white-nose syndrome vaccine trial
An outbreak of rabies occurred in a captive colony of wild-caught big brown bats (Eptesicus fuscus). Five of 27 bats exhibited signs of rabies virus infection 22–51 d after capture or 18–22 d after contact with the index case. Rabid bats showed weight loss, aggression, increased vocalization, hypersalivation, and refusal of food. Antigenic typing and virus sequencing confirmed that all five bats w
Authors
Rachel C. Abbott, L.G. Saindon, Elizabeth Falendysz, Lauren Greenberg, L.A. Orciari, Panayampalli Subbian Satheshkumar, Tonie E. Rocke
Plague positive mouse fleas on mice prior to plague outbreaks in black-tailed and white-tailed prairie dogs
Plague is a lethal zoonotic disease associated with rodents worldwide. In the western United States, plague outbreaks can decimate prairie dog (Cynomys spp.) colonies. However, it is unclear where the causative agent, Yersinia pestis, of this flea-borne disease is maintained between outbreaks, and what triggers plague-induced prairie dog die-offs. Less susceptible rodent hosts, such as mice, could
Authors
Gebbiena M. Bron, Carly Malave, Jesse T. Boulerice, Jorge E. Osorio, Tonie E. Rocke
Virally-vectored vaccine candidates against white-nose syndrome induce anti-fungal immune response in little brown bats (Myotis lucifugus)
White-nose syndrome (WNS) caused by the fungus, Pseudogymnoascus destructans (Pd) has killed millions of North American hibernating bats. Currently, methods to prevent the disease are limited. We conducted two trials to assess potential WNS vaccine candidates in wild-caught Myotis lucifugus. In a pilot study, we immunized bats with one of four vaccine treatments or phosphate-buffered saline (PBS)
Authors
Tonie E. Rocke, Brock Kingstad-Bakke, Marcel Wuthrich, Ben Stading, Rachel C. Abbott, Marcos Isidoro Ayza, Hannah E. Dobson, Lucas dos Santos Dias, Kevin Galles, Julia S. Lankton, Elizabeth Falendysz, Jeffrey M. Lorch, J. Scott Fites, Jaime Lopera-Madrid, Bruce Klein, Jorge E. Osorio, J. Paul White
Quarterly wildlife mortality report January 2019
The USGS National Wildlife Health Center (NWHC) Quarterly Mortality Report provides brief summaries of epizootic mortality and morbidity events by quarter. The write-ups, highlighting epizootic events and other wildlife disease topics of interest, are published in the Wildlife Disease Association quarterly newsletter. A link is provided in this WDA newsletter to the Wildlife Health Information Sha
Authors
Bryan J. Richards, Barbara Bodenstein, Robert J. Dusek, Tonie E. Rocke, Katherine L. D. Richgels
Impact of sylvatic plague vaccine on non-target small rodents in grassland ecosystems
Oral vaccination is an emerging management strategy to reduce the prevalence of high impact infectious diseases within wild animal populations. Plague is a flea-borne zoonosis of rodents that often decimates prairie dog (Cynomys spp.) colonies in the western USA. Recently, an oral sylvatic plague vaccine (SPV) was developed to protect prairie dogs from plague and aid recovery of the endangered bla
Authors
Gebbiena M. Bron, Katherine L. D. Richgels, Samuel. Michael D., Julia E. Poje, Faye Lorenzsonn, Jonathan P. Matteson, Jesse T. Boulerice, Jorge E. Osorio, Tonie E. Rocke
Local factors associated with on‐host flea distributions on prairie dog colonies
Outbreaks of plague, a flea‐vectored bacterial disease, occur periodically in prairie dog populations in the western United States. In order to understand the conditions that are conducive to plague outbreaks and potentially predict spatial and temporal variations in risk, it is important to understand the factors associated with flea abundance and distribution that may lead to plague outbreaks. W
Authors
Robin E. Russell, Rachel C. Abbott, Daniel W. Tripp, Tonie E. Rocke
Factors influencing uptake of sylvatic plague vaccine baits by prairie dogs
Sylvatic plague vaccine (SPV) is a virally vectored bait-delivered vaccine expressing Yersinia pestis antigens that can protect prairie dogs (Cynomys spp.) from plague and has potential utility as a management tool. In a large-scale 3-year field trial, SPV-laden baits containing the biomarker rhodamine B (used to determine bait consumption) were distributed annually at a rate of approximately 100–
Authors
Rachel C. Abbott, Robin E. Russell, Katherine Richgels, Daniel W. Tripp, Marc R. Matchett, Dean E. Biggins, Tonie E. Rocke
Assessing monkeypox virus prevalence in small mammals at the human-animal interface in the Democratic Republic of the Congo
During 2012, 2013 and 2015, we collected small mammals within 25 km of the town of Boende in Tshuapa Province, the Democratic Republic of the Congo. The prevalence of monkeypox virus (MPXV) in this area is unknown; however, cases of human infection were previously confirmed near these collection sites. Samples were collected from 353 mammals (rodents, shrews, pangolins, elephant shrews, a potamoga
Authors
Jeffrey B. Doty, Jean M. Malekani, Lem's N. Kalemba, William T. Stanley, Benjamin P. Monroe, Yoshinori J. Nakazawa, Matthew R. Mauldin, Trésor L. Bakambana, Tobit Liyandja Dja Liyandja, Zachary Braden, Ryan Wallace, Divin V. Malekani, Andrea M. McCollum, Nadia Gallardo-Romero, Ashley Kondas, A. Townsend Peterson, Jorge E. Osorio, Tonie E. Rocke, Kevin L. Karem, Ginny L. Emerson, Darin S. Carroll
Protection of bats (Eptesicus fuscus) against rabies following topical or oronasal exposure to a recombinant raccoon poxvirus vaccine
Rabies is an ancient neglected tropical disease that causes tens of thousands of human deaths and millions of cattle deaths annually. In order to develop a new vaccine for potential use in bats, a reservoir of rabies infection for humans and animals alike, an in silico antigen designer tool was used to create a mosaic glycoprotein (MoG) gene using available sequences from the rabies Phylogroup I g
Authors
Ben Stading, James A. Ellison, William C. Carson, Panayampalli Subbian Satheshkumar, Tonie E. Rocke, Jorge E. Osorio
Burrow dusting or oral vaccination prevents plague-associated prairie dog colony collapse
Plague impacts prairie dogs (Cynomys spp.), the endangered black-footed ferret (Mustela nigripes) and other sensitive wildlife species. We compared efficacy of prophylactic treatments (burrow dusting with deltamethrin or oral vaccination with recombinant “sylvatic plague vaccine” [RCN-F1/V307]) to placebo treatment in black-tailed prairie dog (C. ludovicianus) colonies. Between 2013 and 2015, we m
Authors
Daniel W. Tripp, Tonie E. Rocke, Jonathan P. Runge, Rachel C. Abbott, Michael W. Miller
Characterization of Monkeypox virus infection in African rope squirrels (Funisciurus sp.)
Monkeypox (MPX) is a zoonotic disease endemic in Central and West Africa and is caused by Monkeypox virus (MPXV), the most virulent Orthopoxvirus affecting humans since the eradication of Variola virus (VARV). Many aspects of the MPXV transmission cycle, including the natural host of the virus, remain unknown. African rope squirrels (Funisciurus spp.) are considered potential reservoirs of MPXV, a
Authors
Elizabeth Falendysz, Juan G. Lopera, Jeffrey B. Doty, Yoshinori J. Nakazawa, Colleen Crill, Faye Lorenzsonn, Lem's N. Kalemba, Monica Ronderos, Andres Meija, Jean M. Malekani, Kevin L. Karem, Darrin Caroll, Jorge E. Osorio, Tonie E. Rocke
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Differential plague susceptibility in species and populations of prairie dogs
Laboratory trials conducted over the past decade at U.S. Geological Survey National Wildlife Health Center indicate that wild populations of prairie dogs (Cynomys spp.) display different degrees of susceptibility to experimental challenge with fully virulent Yersinia pestis, the causative agent of plague. We evaluated patterns in prairie dog susceptibility to plague to determine whether the historAuthorsRobin E. Russell, Daniel W. Tripp, Tonie E. RockeRabies outbreak in captive big brown bats (Eptesicus fuscus) used in white-nose syndrome vaccine trial
An outbreak of rabies occurred in a captive colony of wild-caught big brown bats (Eptesicus fuscus). Five of 27 bats exhibited signs of rabies virus infection 22–51 d after capture or 18–22 d after contact with the index case. Rabid bats showed weight loss, aggression, increased vocalization, hypersalivation, and refusal of food. Antigenic typing and virus sequencing confirmed that all five bats wAuthorsRachel C. Abbott, L.G. Saindon, Elizabeth Falendysz, Lauren Greenberg, L.A. Orciari, Panayampalli Subbian Satheshkumar, Tonie E. RockePlague positive mouse fleas on mice prior to plague outbreaks in black-tailed and white-tailed prairie dogs
Plague is a lethal zoonotic disease associated with rodents worldwide. In the western United States, plague outbreaks can decimate prairie dog (Cynomys spp.) colonies. However, it is unclear where the causative agent, Yersinia pestis, of this flea-borne disease is maintained between outbreaks, and what triggers plague-induced prairie dog die-offs. Less susceptible rodent hosts, such as mice, couldAuthorsGebbiena M. Bron, Carly Malave, Jesse T. Boulerice, Jorge E. Osorio, Tonie E. RockeVirally-vectored vaccine candidates against white-nose syndrome induce anti-fungal immune response in little brown bats (Myotis lucifugus)
White-nose syndrome (WNS) caused by the fungus, Pseudogymnoascus destructans (Pd) has killed millions of North American hibernating bats. Currently, methods to prevent the disease are limited. We conducted two trials to assess potential WNS vaccine candidates in wild-caught Myotis lucifugus. In a pilot study, we immunized bats with one of four vaccine treatments or phosphate-buffered saline (PBS)AuthorsTonie E. Rocke, Brock Kingstad-Bakke, Marcel Wuthrich, Ben Stading, Rachel C. Abbott, Marcos Isidoro Ayza, Hannah E. Dobson, Lucas dos Santos Dias, Kevin Galles, Julia S. Lankton, Elizabeth Falendysz, Jeffrey M. Lorch, J. Scott Fites, Jaime Lopera-Madrid, Bruce Klein, Jorge E. Osorio, J. Paul WhiteQuarterly wildlife mortality report January 2019
The USGS National Wildlife Health Center (NWHC) Quarterly Mortality Report provides brief summaries of epizootic mortality and morbidity events by quarter. The write-ups, highlighting epizootic events and other wildlife disease topics of interest, are published in the Wildlife Disease Association quarterly newsletter. A link is provided in this WDA newsletter to the Wildlife Health Information ShaAuthorsBryan J. Richards, Barbara Bodenstein, Robert J. Dusek, Tonie E. Rocke, Katherine L. D. RichgelsImpact of sylvatic plague vaccine on non-target small rodents in grassland ecosystems
Oral vaccination is an emerging management strategy to reduce the prevalence of high impact infectious diseases within wild animal populations. Plague is a flea-borne zoonosis of rodents that often decimates prairie dog (Cynomys spp.) colonies in the western USA. Recently, an oral sylvatic plague vaccine (SPV) was developed to protect prairie dogs from plague and aid recovery of the endangered blaAuthorsGebbiena M. Bron, Katherine L. D. Richgels, Samuel. Michael D., Julia E. Poje, Faye Lorenzsonn, Jonathan P. Matteson, Jesse T. Boulerice, Jorge E. Osorio, Tonie E. RockeLocal factors associated with on‐host flea distributions on prairie dog colonies
Outbreaks of plague, a flea‐vectored bacterial disease, occur periodically in prairie dog populations in the western United States. In order to understand the conditions that are conducive to plague outbreaks and potentially predict spatial and temporal variations in risk, it is important to understand the factors associated with flea abundance and distribution that may lead to plague outbreaks. WAuthorsRobin E. Russell, Rachel C. Abbott, Daniel W. Tripp, Tonie E. RockeFactors influencing uptake of sylvatic plague vaccine baits by prairie dogs
Sylvatic plague vaccine (SPV) is a virally vectored bait-delivered vaccine expressing Yersinia pestis antigens that can protect prairie dogs (Cynomys spp.) from plague and has potential utility as a management tool. In a large-scale 3-year field trial, SPV-laden baits containing the biomarker rhodamine B (used to determine bait consumption) were distributed annually at a rate of approximately 100–AuthorsRachel C. Abbott, Robin E. Russell, Katherine Richgels, Daniel W. Tripp, Marc R. Matchett, Dean E. Biggins, Tonie E. RockeAssessing monkeypox virus prevalence in small mammals at the human-animal interface in the Democratic Republic of the Congo
During 2012, 2013 and 2015, we collected small mammals within 25 km of the town of Boende in Tshuapa Province, the Democratic Republic of the Congo. The prevalence of monkeypox virus (MPXV) in this area is unknown; however, cases of human infection were previously confirmed near these collection sites. Samples were collected from 353 mammals (rodents, shrews, pangolins, elephant shrews, a potamogaAuthorsJeffrey B. Doty, Jean M. Malekani, Lem's N. Kalemba, William T. Stanley, Benjamin P. Monroe, Yoshinori J. Nakazawa, Matthew R. Mauldin, Trésor L. Bakambana, Tobit Liyandja Dja Liyandja, Zachary Braden, Ryan Wallace, Divin V. Malekani, Andrea M. McCollum, Nadia Gallardo-Romero, Ashley Kondas, A. Townsend Peterson, Jorge E. Osorio, Tonie E. Rocke, Kevin L. Karem, Ginny L. Emerson, Darin S. CarrollProtection of bats (Eptesicus fuscus) against rabies following topical or oronasal exposure to a recombinant raccoon poxvirus vaccine
Rabies is an ancient neglected tropical disease that causes tens of thousands of human deaths and millions of cattle deaths annually. In order to develop a new vaccine for potential use in bats, a reservoir of rabies infection for humans and animals alike, an in silico antigen designer tool was used to create a mosaic glycoprotein (MoG) gene using available sequences from the rabies Phylogroup I gAuthorsBen Stading, James A. Ellison, William C. Carson, Panayampalli Subbian Satheshkumar, Tonie E. Rocke, Jorge E. OsorioBurrow dusting or oral vaccination prevents plague-associated prairie dog colony collapse
Plague impacts prairie dogs (Cynomys spp.), the endangered black-footed ferret (Mustela nigripes) and other sensitive wildlife species. We compared efficacy of prophylactic treatments (burrow dusting with deltamethrin or oral vaccination with recombinant “sylvatic plague vaccine” [RCN-F1/V307]) to placebo treatment in black-tailed prairie dog (C. ludovicianus) colonies. Between 2013 and 2015, we mAuthorsDaniel W. Tripp, Tonie E. Rocke, Jonathan P. Runge, Rachel C. Abbott, Michael W. MillerCharacterization of Monkeypox virus infection in African rope squirrels (Funisciurus sp.)
Monkeypox (MPX) is a zoonotic disease endemic in Central and West Africa and is caused by Monkeypox virus (MPXV), the most virulent Orthopoxvirus affecting humans since the eradication of Variola virus (VARV). Many aspects of the MPXV transmission cycle, including the natural host of the virus, remain unknown. African rope squirrels (Funisciurus spp.) are considered potential reservoirs of MPXV, aAuthorsElizabeth Falendysz, Juan G. Lopera, Jeffrey B. Doty, Yoshinori J. Nakazawa, Colleen Crill, Faye Lorenzsonn, Lem's N. Kalemba, Monica Ronderos, Andres Meija, Jean M. Malekani, Kevin L. Karem, Darrin Caroll, Jorge E. Osorio, Tonie E. Rocke - News