Dissolution has removed large volumes of rock at low-angle normal faults, i.e., detachment faults, in the Mormon Mountains and the Tule Springs Hills in the eastern Basin and Range Province, southeastern Nevada. Evidence for major dissolution includes widespread solution-collapse breccias, meter-scale stylolite structures, and high-angle accommodation faults that terminate at or merge with dissolution seams. Chemically reactive fluids moving along the fault zones led to a strong depletion of 18O in the detachment fault breccias (e.g., a δ18O decrease of 8‰ relative to the unaltered rocks). These strong chemical shifts, demonstrated by (1) negative oxygen isotope values and (2) steep compositional gradients marked by metal enrichment in elements such as Au, Ag, Ti, Pb, Zn, and Cu, are generally restricted to the narrow (