There is no record of mineral production, development, or prospecting within the study area. Rock units that underlie the Herculese Glades Wilderness at depth are known to be hosts of important lead-zinc-silver deposits of southeast Missouri and minor outcrops of rocks that host the zinc and lead deposits of the Tri-State district occur within the area. No drill-hole data are available within the wilderness, and geochemical surveys did not reveal any significant mineralization at the surface. Based on our present knowledge, the mineral resource potential of the study area is considered low.