Uranium and lead isotopic analyses of monazlte and uraninite from the disseminated uraninite occurrence at Wheeler Basin, Grand County, Colo., indicate that these minerals formed 1,446±20 m.y. ago. This time correlates well with intrusion of the Silver Plume Granite. The uraninite and monazite were also affected by a later disturbance at 880±130 m.y., but show essentially no effects of subsequent events. This secondary disturbance may have been due to intrusion of dikes related to the Pikes Peak batholith, dated at 1,041±13 m.y. ago.