The Talkeetna 1° by 3° quadrangle, which consists of about 17,155 km2 in south-central Alaska, was investigated by integrated field and laboratory studies in the disciplines of geology, geochemistry, geophysics, and Landsat data interpretation for the purpose of assessing its mineral resource potential. Past mineral production has been limited to gold from the Yentna district, but the quadrangle contains potentially significant resources of tin and silver and possibly a few other commodities including chromite and copper. The results of the mineral resource assessment are given in a folio of maps which are accompanied by descriptive texts, diagrams, tables, and pertinent references. This Circular provides background information on these investigations and integrates the component maps. A bibliography cites both specific and general references to the geology and mineral deposits of the quadrangle.