In the first study on this scale, distribution and transport of selected hydrophobic halogenated organic compounds associated with suspended sediment from the lower Mississippi River and its principal tributaries were determined during two spring and two summer cruises. Lipophilic organic compounds identified on the suspended sediment included hexachlorobenzene, pentachlorobenzene, pentachloroanisole, dacthal, chlordane (cis- and trans- ), nonachlor (trans-), chlorthalonil, and penta-, hexa-, hepta-, and octachlorobiphenyls. Most of these compounds come from nonpoint sources. Mass loadings of most of the compounds increased from upstream to downstream on the main stem of the Mississippi River. Of the tributaries studied, the Ohio River had the most significant effect on contaminant loads. Suspended sediment transport to the Gulf of Mexico of the most abundant, widely distributed compound class, PCBs, was estimated at 6,750 kg per year.