This third six-month progress report to the Environmental Health Center of the University of Missouri marks the midway point in our studies of the environmental geochemistry of the State. Over 4,000 samples of rocks, soils, vegetation, and groundwater have been collected from throughout the State; most of these are currently in the Geological Survey laboratories under various stages of preparation and analysis. Some preliminary results have been reported in the two previous progress reports, and others are presented here. It is expected that the major part of the analytical task will be completed in the next 6 to 12 months, however, and forthcoming reports should include information of direct application to the epidemiological investigations of the Environmental Health Center. The present report is intended to inform those concerned of our progress, our plans for the forthcoming final field season of the investigation, and to offer some additional preliminary results. Of specific interest to the Environmental Health Center will be the maps showing localities throughout the State where samples, or groups of samples, of rocks, soils, vegetation, and water have been collected so far; the sampling plans have been discussed briefly in the previous progress reports, and will be described in detail, of course, in forthcoming reports along with analyses and interpretations of the laboratory data.