Geophysical logs from wells distributed throughout the Powder River Basin were digitized, processed, and interpreted to get a regional understanding of the lithologic and ground-water characteristics of aquifers in the Madison Limestone and Minnelusa Formation. The percentage of sand, porosity, and apparent ground-water resistivity of the Minnelusa closely follow structural trends in the basin. Values increase from the structural axis of the basin toward the flanks. Close correlations between the water resistivities in the Madison and the Minnelusa indicate possible hydrologic connection between the two units. The low primary porosity from geophysical logs in the Madison indicates that secondary porosity is necessary to develop water supplies of economic importance from the Madison. Because of increased porosity and better water quality, the flanks of the basin appear to be the most favorable places for water production from either the Madison or the Minnelusa.