At Lake Mead, contrasts in permeability of upper Cenozoic sediments show a better correlation with irregularly distributed impoundment-related seismicity than do contrasts in structure. An evaluation of structures developed during the late Cenozoic fails to explain the erratic distribution of seismicity. An evaluation of the late Cenozoic stratigraphy, however, shows a concentration of relatively impermeable evaporite beds and fine-grained clastic strata in the less seismic part of the lake basin; therefore, the authors conclude that a hydraulic connection between the lake water and the deep aquifer system that includes buried faults is needed in the Lake Mead area to cause the release of seismic energy. Where hydraulic connection is prevented by continuous or quasi-continuous upper Cenozoic basin-fill strata of low permeability, as in the eastern basin area, seismicity does not occur.