The San Francisco Bay-Delta estuary and its watershed have been a focus of intense human activity and environmental impact since 1848 when gold was discovered in the foothills of California's Sierra Nevada mountains. As the estuary and its watershed continue to be changed by human activities, resource managers, environmental regulators, elected officials, and the public seek credible, unbiased scientific information about the factors related to observed changes in order to restore impaired species, habitats and ecological functions.