Streamflow and water-quality data were collected throughout the Little Scrubgrass Creek basin, Venango and Butler Counties, Pennsylvania, from December 1987 to November 1988, to determine the prevailing quality of surface water throughout the basin. This data will assist the Pennsylvania Department of Environmental Resources during its review of coal mine permit applications. A water-quality station on Little Scrubgrass Creek near Lisbon, provided continuous-record of stream stage, pH, specific conductance, and water temperature. Monthly water-quality samples collected at this station were analyzed for total and dissolved metals, nutrients, major cations and anions, and suspended sediment concentrations. Fourteen partial-record sites, located throughout the basin, were similarly sampled four times during the period of study. Streamflow and water-quality data obtained at these sites during various base flow periods are also presented.