Streamflow and water-quality data were collected throughout the Meadow Run basin, Fayette County, Pennsylvania, from December 7, 1987 through November 15, 1988, to determine the prevailing quality of surface water over a range of hydrologic conditions. This data will assist the Pennsylvania Department of Environmental Resources during its review of coal-mine permit applications. A water-quality station near the mouth of Meadow Run provided continuous-record of stream stage, pH, specific conductance, and water temperature. Monthly water-quality samples collected at this station were analyzed for total and dissolved metals, nutrients, major cations and anions, and suspended-sediment concentrations. Fourteen partial-record sites, located throughout the basin, were similarly sampled four times during the study. Streamflow and water-quality data obtained at these sites during a winter base flow, a spring rainfall event, a summer rainfall event, and a low summer base flow also are presented.