A reconnaissance study of 28 trace metals in samples of surface soil (0-2.5 cm deep), subsurface soil (15-20 cm deep), and big sagebrush (Artemisia tridentata) that were collected from the Powder River Basin in Wyoming and Montana indicates that little variation occurs in nature at scales greater than about 35 km. This general lack of broadscale variation suggests that simple summary statistics for these materials could provide basinwide geochemical baselines for use in monitoring secular changes in the local geochemical environment. Samples of big sagebrush near the Dave Johnston Power Plant at the southern edge of the basin exhibit statistically significant reductions of strontium, vanadium, uranium, and selenium eastward from the plant.