The Upper Colorado River Basin is 1 of 60 study units selected for water-quality assessment by the U.S. Geological Survey as part of the National Water-Quality Assessment program. Understanding the environmental setting of the Upper Colorado River Basin study unit is important in evaluating water-quality issues in the basin. Information about the environmental setting identifies the basin characteristics and includes natural and human factors that affect the physical, chemical, and biological quality of water in the basin. This information has been used to design surface-water- and ground-water-quality sampling networks in the basin to assess overall water quality of the basin