This data release is part of a 2016-2019 study on the geology, geochemistry and geochronology of ore systems in the eastern Yukon-Tanana Upland region, Alaska. Whole rock chemistry was conducted on 185 samples, mostly from Au prospects, with lesser samples from porphyry Cu prospects. Geographically, most samples are from gold prospects near the Pogo Au mine and east to Black Mountain in the Big Delta quadrangle. Fewer samples are from prospects in the Eagle and Tanacross Quadrangles. Samples were submitted to the USGS contract laboratory and analyzed for select trace elements and gold. Sixty elements were determined by inductively coupled plasma-optical emission spectroscopy-mass spectroscopy (ICP-OES-MS), sodium peroxide fusion (ICP-60). Gold was determined by lead fusion fire assay.