Burmese pythons (Python bivittatus) is a large, invasive reptile known in Florida for its devastating impacts on native species in the Greater Everglades Ecosystem. Several organizations and individuals are taking action to research and/or remove the snakes, including the U.S. Geological Survey (USGS). Since 2018, scientists from USGS’s Fort Collins Science Center have been working closely with the National Park Service (NPS) in Big Cypress National Preserve to use radiotelemetry and track Burmese pythons for various ecological research project and management (enabled by invaluable partnerships with the University of Florida and Zoo Miami). Over those years, we have encountered some incidental, but intriguing findings.