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Broad-spectrum antiviral JL122 blocks infection and inhibits transmission of aquatic rhabdoviruses

October 23, 2018

The aquaculture industry is growing rapidly to meet the needs for global protein consumption. Viral diseases in aquaculture are quite challenging due to lack of treatment options as well as limited injection-delivery vaccines, which are costly. Thus, water-immersion antiviral treatments are highly desirable. This study focused on broad-spectrum, light-activated antivirals that target the viral membrane (envelope) of viruses to prevent viral-cell membrane fusion, ultimately blocking viral entry into cells. Of the tested small-molecules, JL122, a new broad-spectrum antiviral previously unexplored against aquatic viruses, blocked infection of three aquatic rhabdoviruses (IHNV, VHSV and SVCV) in cell culture and in two live fish challenge models. Importantly, JL122 inhibited transmission of IHNV from infected to uninfected rainbow trout. Further, the effective antiviral concentrations were not toxic to cells or susceptible fish. These results show promise for JL122 to become an immersion treatment option for outbreaks of aquatic enveloped viral infections.

Citation Information

Publication Year 2018
Title Broad-spectrum antiviral JL122 blocks infection and inhibits transmission of aquatic rhabdoviruses
DOI 10.1016/j.virol.2018.09.009
Authors Bethany F. Balmer, Rodman G. Getchell, Rachel L. Powers, Jihye Lee, Tinghu Zhang, Michael E. Jung, Maureen K. Purcell, Kevin Snekvik, Hector C. Aguilar
Publication Type Article
Publication Subtype Journal Article
Series Title Virology
Index ID 70200541
Record Source USGS Publications Warehouse
USGS Organization Western Fisheries Research Center