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Hepatic glutathione metabolism and lipid peroxidation in response to excess dietary selenomethionine and selenite in mallard ducklings

January 1, 1989

Selenium from selenomethionine accumulated in a dose-dependent manner in the liver, resulting in a decrease in hepatic-reduced glutathione with a corresponding decrease in total hepatic thiols. There was a dose-dependent increase in the oxidized to reduced glutathione ratio, and an increase in lipid peroxidation. These findings indicate that Se in the diet at 10 ppm and higher causes significant sublethal alterations in mallard ducklings, and 20-40 ppm causes significant hepatotoxicity.

Publication Year 1989
Title Hepatic glutathione metabolism and lipid peroxidation in response to excess dietary selenomethionine and selenite in mallard ducklings
DOI 10.1080/15287398909531296
Authors D. J. Hoffman, G. H. Heinz, A. J. Krynitsky
Publication Type Article
Publication Subtype Journal Article
Series Title Journal of Toxicology and Environmental Health
Index ID 5222272
Record Source USGS Publications Warehouse
USGS Organization Patuxent Wildlife Research Center
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