Involvement of rainbow trout leucocytes in the pathogenesis of infectious hematopoietic necrosis
January 1, 1994
Rainbow trout Oncorhynchus myluss leucocytes were tested for their ability to support replication of infectious hematopoietic necrosis virus (IHNV). Viral replication occurred in vitro uslng leucocytes cultured from peripheral blood, kidney, and thymus where viral titers peaked at 2 to 4 d post-inoculation. Leucocytes collected from trout following waterborne challenge with IHNV were cocultured on EPC cell monolayers. These assays detected IHNV in leucocytes infected in vivo as early as 6 h post-exposure before the challenge virus had undergone replication. These data showed that leucocyte populations could serve as target cells in the initial phase of IHNV infection.
Citation Information
Publication Year | 1994 |
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Title | Involvement of rainbow trout leucocytes in the pathogenesis of infectious hematopoietic necrosis |
DOI | 10.3354/DAO019089 |
Authors | S. Chilmonczyk, J. R. Winton |
Publication Type | Article |
Publication Subtype | Journal Article |
Series Title | Diseases of Aquatic Organisms |
Index ID | 70180356 |
Record Source | USGS Publications Warehouse |
USGS Organization | Western Fisheries Research Center |