Limits of retrospective power analysis

Power analysis after study completion has been suggested to interpret study results. We present 3 methods of estimating power and discuss their limitations. We use simulation studies to show that estimated power can be biased, extremely variable, and severely bounded. We endorse the practice of computing power to detect a biologically meaningful difference as a tool for study planning but suggest that calculation of confidence intervals on the parameter of interest is the appropriate way to gauge the strength and biological meaning of study results.