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The oxidation of drugs by fishes

January 1, 1968

1. Fish liver microsomal systems have been found to catalyze the hydroxylation of aniline and acetanilide, the N-demethylation of aminopyrine and the O-dealkylation of phenacetin.
2. These systems are similar to the corresponding mammalian enzymes and they may be considered to be mixed function oxidase since they require NADPH and oxygen. An absolute requirement for oxygen, however, was difficult to demonstrate for the hepatic phenacetin cleavage system from fish.
3. Microsomal drug metabolizing systems from fish have temperature optima which are considerably lower than those of corresponding mammalian systems

Publication Year 1968
Title The oxidation of drugs by fishes
DOI 10.1016/0010-406X(68)90931-6
Authors Donald R. Buhler, Mary E. Rasmusson
Publication Type Article
Publication Subtype Journal Article
Series Title Comparative Biochemistry and Physiology, Part A: Molecular & Integrative Physiology
Index ID 70171222
Record Source USGS Publications Warehouse
USGS Organization Columbia Environmental Research Center