The U.S. Geological Survey and The Nature Conservancy previously collaborated to evaluate changes and trends in the concentrations and flux of nutrients (total phosphorus, as phosphorus; nitrate plus nitrite, as nitrogen; and total Kjeldahl nitrogen, as nitrogen) and total suspended solids (TSS) at three study gages located on the upper White River at Muncie, near Nora, and near Centerton, Indiana. That work is extended and updated using 3 additional years of data (through 2020) and newer estimation methods. In addition, information is provided about climatic and anthropogenic factors that could influence the concentrations and fluxes of nutrients and TSS in the upper White River Basin.