Protection of black-tailed prairie dogs (Cynomys ludovicianus) against plague after voluntary consumption of baits containing recombinant raccoon poxvirus vaccine
January 1, 2004
Prairie dogs (Cynomys spp.) are highly susceptible to Yersinia pestis and significant reservoirs of plague for humans in the western United States. A recombinant raccoon poxvirus, expressing the F1 antigen of Y. pestis, was incorporated into a palatable bait and offered to 18 black-tailed prairie dogs (Cynomys ludovicianus) for voluntary consumption; 18 negative control animals received placebo baits. Antibody titers against Y. pestis F1 antigen increased significantly (P < 0.01) in vaccinees, and their survival was significantly higher upon challenge with Y. pestis than that of negative controls (P < 0.01).
Citation Information
Publication Year | 2004 |
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Title | Protection of black-tailed prairie dogs (Cynomys ludovicianus) against plague after voluntary consumption of baits containing recombinant raccoon poxvirus vaccine |
DOI | 10.1128/IAI.72.9.5502-5505.2004 |
Authors | J.S. Mencher, S.R. Smith, T.D. Powell, D.T. Stinchcomb, J.E. Osorio, T.E. Rocke |
Publication Type | Article |
Publication Subtype | Journal Article |
Series Title | Infection and Immunity |
Index ID | 1003728 |
Record Source | USGS Publications Warehouse |
USGS Organization | National Wildlife Health Center |