Trends in agricultural triazole fungicide sse in the United States, 1992–2016 and possible implications for antifungal-resistant fungi in human disease

Background:>4-fold>4-fold during 2006–2016 to 2.9 million kg2.9 million kg in 2016. During 1992–2005, triazole fungicide use occurred mostly in orchards and grapes, wheat, and other crops, but recent increases in use have occurred primarily in wheat, corn, soybeans, and other crops, particularly in Midwest and Southeast states. We conclude that, given the chemical similarities between triazole fungicides and triazole antifungal drugs used in human medicine, increased monitoring for environmental and clinical triazole resistance in A. fumigatus would improve overall understanding of these interactions, as well as help identify strategies to mitigate development and spread of resistance.