This U.S. Geological Survey (USGS) data release includes whole-rock major, trace, and rare earth element geochemical data, whole-rock Nd-Pb-Sr isotopic data collected by thermal ionization mass spectrometry (TIMS), and zircon U-Pb isotopic data collected by laser ablation-inductively coupled mass spectrometry (LA-ICP-MS) methods. These data provide constraints on, and characterize, the composition and ages of crystalline basement rocks in the western United States, supporting geologic mapping and mineral systems analysis of critical mineral deposits.