Although the Rock Pile Mountain Wilderness Study Area is within the general boundary of the Southeast Missouri mining district, it has no record of mineral production and there is no mining or prospecting activity at present. Exploratory drill holes on private land along the west side of the area encountered no economic mineralization.
Neither the Precambrlan volcanic rocks nor the Cambrlan sedimentary rocks contain any detectable evidence of economic mineralization. The area has no potential for coal resources, an unfavorable potential for oil and gas, and no known potential for geothermal energy. The volcanic rocks might be suitable for use as crushed stone, but similar rocks occur abundantly in more favorable locations elsewhere.