Significant quantities of recoverable natural gas resources are estimated to be in the regionally extensive Lower Silurian Medina Group and “Clinton” sandstone of the Appalachian Basin (Gautier and others, 1995; Ryder and others, 1996; Ryder, 1998). In order to assess these accumulations of natural gas more accurately, the U.S. Geological Survey (USGS) has investigated the Silurian stratigraphy along six lines of cross section located in New York, Pennsylvania, Ohio, and West Virginia (fig. 1). Cross section A–A' extends about 375 mi from northeast to southwest and is oriented approximately parallel to the nearby paleoshoreline of the Silurian epeiric sea. The remaining cross sections extend about 100–200 mi from northwest to southeast and are oriented nearly perpendicular to the paleoshoreline. Stratigraphic investigations along A–A' were reported by Ryder (2000), correlations along D–D' were reported by Keighin (1998), and investigations along E–E' and F–F' were in progress at the time of this publication. This report provides correlations for Silurian strata along cross sections B–B' and C–C', which are located in the northern part of the Appalachian Basin (figs. 1 and 2). Cross section B–B' extends about 140 mi from Chautauqua County, N.Y., to Clinton County, Pa., and C–C' extends about 200 mi from Lake County, Ohio, to Clinton County, Pa. Correlations are made along B–B' and C–C' for the Lower Silurian Medina and Clinton Groups, Lower Silurian Tuscarora and Rose Hill Formations, and Lower and Upper Silurian Lockport Group and Mifflintown Formation (lower part). Emphasis is placed on the Medina Group because it is the principal natural gas reservoir in the Silurian deposit.