Encompassing over 175 million acres, America’s “Sagebrush Sea” is the largest terrestrial ecosystem in the lower 48 states. The impacts of climate change, wildfire, and invasive annual grasses, coupled with impacts from human activity, threatens the ability of sagebrush landscapes to sustain biological, economic, and cultural values. Loss of sagebrush landscapes, including the loss of important native grasses and forbs, is driven largely by invasive annual grasses and the associated impacts from large wildfires, resulting in landscape scale change that can be difficult to restore. USGS is partnering with federal, state, tribal and NGO partners to coproduce science to inform management actions, prioritization, and evaluate restoration outcomes to arrest an average loss of 1.3 million acres, most of that to rangeland fire and invasive annual grasses.