The amplification of strong ground motion at sites in the greater Los Angeles, California, region is determined using the generalized-inverse method of Andrews (1986). Site-amplification estimates are determined at 281 strong-motion sites that provided horizontal-component accelerograms from the 1971 San Fernando, 1987 Whittier Narrows, 1991 Sierra Madre, or 1994 Northridge mainshocks. The estimates are determined relative to the spectral level recorded at a single reference site. In a second inversion, a source-site interaction term is added to Andrews's (1986) model to quantify the effect selected mainshock records have on site-amplification estimates. The source-site interaction term is applied to the San Fernando Valley sites' records of the Northridge earthquake and to three Los Angeles basin sites' records of the Whittier Narrows mainshock.