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Discovery of a novel hepatovirus (Phopivirus of seals) related to human hepatitis A virus

August 25, 2015

Describing the viral diversity of wildlife can provide interesting and useful insights into the natural history of established human pathogens. In this study, we describe a previously unknown picornavirus in harbor seals (tentatively named phopivirus) that is related to human hepatitis A virus (HAV). We show that phopivirus shares several genetic and phenotypic characteristics with HAV, including phylogenetic relatedness across the genome, a specific and seemingly quiescent tropism for hepatocytes, structural conservation in a key functional region of the type III internal ribosomal entry site (IRES), and a codon usage bias consistent with that of HAV.

Citation Information

Publication Year 2015
Title Discovery of a novel hepatovirus (Phopivirus of seals) related to human hepatitis A virus
DOI 10.1128/mBio.01180-15
Authors Anthony. S.J., J.A St. Leger, E. Liang, A.L. Hicks, M.D Sanchez-Leon, Hon S. Ip, K. Jain, J. H. Lefkowitch, I. Navarrete-Macias, N. Knowles, T. Goldstein, K. Pugliares, T. Rowles, W.I. Lipkin
Publication Type Article
Publication Subtype Journal Article
Series Title mBio
Index ID 70159761
Record Source USGS Publications Warehouse
USGS Organization National Wildlife Health Center

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