Environmental factors affecting contaminant toxicity in aquatic and terrestrial vertebrates

Environmental factors have long been demonstrated to influence the toxicity of pollutants to vertebrates. The vast majority of data has been derived from studies on fish, highly inbred laboratory rodents, and man.^1,2 The magnitude and significance of these factors on toxicity has almost exclusively been elucidated in controlled experiments conducted in a laboratory setting. The significance of such effects to free-ranging vertebrate wildlife is frequently overlooked. Drawing upon controlled experiments and observational science, we overview environmental factors that influence pollutant toxicity in fish and wildlife, and attempt to present some perspective on their ecotoxicological significance.