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The evolution of vertebrate Toll-like receptors

January 1, 2005

The complete sequences of Takifugu Toll-like receptor (TLR) loci and gene predictions from many draft genomes enable comprehensive molecular phylogenetic analysis. Strong selective pressure for recognition of and response to pathogen-associated molecular patterns has maintained a largely unchanging TLR recognition in all vertebrates. There are six major families of vertebrate TLRs. This repertoire is distinct from that of invertebrates. TLRs within a family recognize a general class of pathogen-associated molecular patterns. Most vertebrates have exactly one gene ortholog for each TLR family. The family including TLR1 has more species-specific adaptations than other families. A major family including TLR11 is represented in humans only by a pseudogene. Coincidental evolution plays a minor role in TLR evolution. The sequencing phase of this study produced finished genomic sequences for the 12 Takifugu rubripes TLRs. In addition, we have produced > 70 gene models, including sequences from the opossum, chicken, frog, dog, sea urchin, and sea squirt. ?? 2005 by The National Academy of Sciences of the USA.

Publication Year 2005
Title The evolution of vertebrate Toll-like receptors
DOI 10.1073/pnas.0502272102
Authors J.C. Roach, G. Glusman, L. Rowen, A. Kaur, M. K. Purcell, K.D. Smith, L.E. Hood, A. Aderem
Publication Type Article
Publication Subtype Journal Article
Series Title Proceedings of the National Academy of Sciences of the United States of America
Index ID 70029624
Record Source USGS Publications Warehouse