Seismic velocity structure of the San Francisco Bay region crust is derived using measurements of finite-frequency traveltimes. A total of 57 801 relative traveltimes are measured by cross-correlation over the frequency range 0.5–1.5 Hz. From these are derived 4862 ‘summary’ traveltimes, which are used to derive 3-D P-wave velocity structure over a 341 × 140 km2 area from the surface to 25 km depth. The seismic tomography is based on sensitivity kernels calculated on a spherically symmetric reference model. Robust elements of the derived P-wave velocity structure are: a pronounced velocity contrast across the San Andreas fault in the south Bay region (west side faster); a moderate velocity contrast across the Hayward fault (west side faster); moderately low velocity crust around the Quien Sabe volcanic field and the Sacramento River delta; very low velocity crust around Lake Berryessa. These features are generally explicable with surface rock types being extrapolated to depth ∼10 km in the upper crust. Generally high mid-lower crust velocity and high inferred Poisson's ratio suggest a mafic lower crust.