Annual exceedance probability flows at gaged locations and regional regression equations used to estimate annual exceedance probability flows at ungaged locations were developed by the U.S. Geological Survey, in cooperation with the Mississippi Department of Transportation, to improve flood-frequency estimates at rural streams in the alluvial plain of the lower Mississippi River. These estimates were developed using current geospatial data, analytical methods, and annual peak-flow data through September 2017 at 58 streamgages in the alluvial plain of the lower Mississippi River, including 9 in Mississippi, 35 in Arkansas, 4 in Missouri, and 10 in Louisiana. Annual exceedance probability flows presented in this report incorporate streamflow data through the 2017 water year, 32 additional years of record since the previous study in 1985 of flood magnitude and frequency in the Mississippi portion of the alluvial plain of the lower Mississippi River. Ranges for standard error of prediction, average variance of prediction, and pseudo-R2 are 45–61 percent, 0.035–0.059 (log cubic feet per second)2, and 90–94 percent, respectively.