The impetus for developing this document is through implementing the Rocky Reach Pacific Lamprey Management Plan (PLMP), a component of the Rocky Reach Comprehensive Settlement Agreement, both of which are discussed more thoroughly in Section 1.2. The ultimate goal of the PLMP is to achieve No Net Impact (NNI) to Pacific lamprey of ongoing operations of the Rocky Reach Hydroelectric Project. Conducting artificial propagation of Pacific lamprey was considered by the state and federal fishery agencies and Tribes that are parties to the Settlement Agreement as a potential Protection, Mitigation, and Enhancement measure (PME) for achieving NNI during the term of the current Rocky Reach license. This document is intended to provide guidance as to the feas ibility of culturing Pacific lamprey, the associated facilities necessary for culture practices, and identifying uncertainties for monitoring culture efficacy and rationale for implementing Pacific lamprey artificial propagation