Skip to main content
U.S. flag

An official website of the United States government

Pharmacokinetic modeling in aquatic animals. 1. Models and concepts

January 1, 1990

While clinical and toxicological applications of pharmacokinetics have continued to evolve both conceptually and experimentally, pharmacokinetics modeling in aquatic animals has not progressed accordingly. In this paper we present methods and concepts of pharmacokinetic modeling in aquatic animals using multicompartmental, clearance-based, non-compartmental and physiologically-based pharmacokinetic models. These models should be considered as alternatives to traditional approaches, which assume that the animal acts as a single homogeneous compartment based on apparent monoexponential elimination.

Citation Information

Publication Year 1990
Title Pharmacokinetic modeling in aquatic animals. 1. Models and concepts
Authors M.G. Barron, Guy R. Stehly, W.L. Hayton
Publication Type Article
Publication Subtype Journal Article
Series Title Aquatic Toxicology
Index ID 1003527
Record Source USGS Publications Warehouse
USGS Organization Upper Midwest Environmental Sciences Center