The Ogallala Formation and associated Tertiary and Quarternary deposits form the principal aquifers supporting irrigation in the High Plains of Colorado, Kansas, Nebraska, New Mexico, Oklahoma, South Dakota, Texas, and Wyoming. The volume of water in storage within the aquifers is declining in most of the High Plains because water is being withdrawn in excess of the rate of replenishment. The U.S. Geological Survey has initiated a 5-year study of the High Plains aquifer system to develop the geohydrologic data base and computer models of the ground-water flow system needed to evaluate the response of the aquifer,system to ground-water management alternatives. This report describes the objectives, plan, and organization of the study and outlines the work to be accomplished in each state in the study area.