In 1981 and 1982 we studied the reproductive success of American White Pelicans in the Klamath Basin of northern California. We observed that reproductive success at one colony became reduced in 1981 when we entered that colony to collect eggs for chemical analysis and to mark nests for an assessment of nesting success. Those pelicans produced only 0.5 Y/N contrasted to pelicans nesting at an undisturbed colony that produced about 1.2 Y/N. No colonies were entered in 1982 and both produced about 1.1 Y/N. We concluded that our activities reduced the success of that one disturbed colony. We suggest that the sample-egg technique should not be used in American White Pelican colonies, in-colony activities should be very limited, and researchers in bird colonies should attempt more often to assess the effects of their own activiites