Crossbred coho salmon Oncorhynchus kisutch were produced from all possible crosses among three stocks. The relative susceptibility of the progeny to infection by the myxosporean parasite Ceratomyxa shasta was determined by exposure of juvenile fish to Willamette River water that contained the infective stage of the parasite. Susceptibility of coho salmon native to the Columbia River basin to the disease ceratomyxosis was relatively low whereas that of coho salmon from remote locations was relatively high. Susceptibility of crossbred progeny nearly always was intermediate between the susceptibilities of fish from the parental stocks.