Donald Tillitt, PhD (Former Employee)
Science and Products
Filter Total Items: 215
Correlation of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced apoptotic cell death in the embryonic vasculature with embryotoxicity Correlation of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced apoptotic cell death in the embryonic vasculature with embryotoxicity
Vertebrate embryos are particularly sensitive to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Identification of tissues that are susceptible to the adverse effects of TCDD is requisite for understanding the embryo toxic effects of TCDD. The objective of the present study was to quantitate the temporal appearance of and dose dependence of apoptosis in TCDD-exposed medaka embryos (Oryzias...
Authors
Susannah M. Cantrell, Jennifer Joy-Schlezinger, John J. Stegeman, Donald E. Tillitt, Mark D. Hannington
Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife
An expert meeting was organized by the World Health Organization (WHO) and held in Stockholm on 15-18 June 1997. The objective of this meeting was to derive consensus toxic equivalency factors (TEFs) for polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) and dioxinlike polychlorinated biphenyls (PCBs) for both human, fish, and wildlife risk assessment. Based on existing...
Authors
M. Van den Berg, L. Birnbaum, A. T. C. Bosveld, B. Brunstrom, P. Cook, M. Feeley, J. P. Giesy, A. Hanberg, R. Hasegawa, S. W. Kennedy, T. Kubiak, J. C. Larsen, F. X. R. Van Leeuwen, A. K. D. Liem, C. Nolt, R. E. Peterson, L. Poellinger, S. Safe, D. Schrenk, Donald E. Tillitt, M. Tysklind, M. Younes, F. Waern, T. Zacharewski
Estimation of uptake rate constants for PCB congeners accumulated by semipermeable membrane devices and brown treat (Salmo trutta) Estimation of uptake rate constants for PCB congeners accumulated by semipermeable membrane devices and brown treat (Salmo trutta)
The triolein-filled semipermeable membrane device (SPMD) is a simple and effective method of assessing the presence of waterborne hydrophobic chemicals. Uptake rate constants for individual chemicals are needed to accurately relate the amounts of chemicals accumulated by the SPMD to dissolved water concentrations. Brown trout and SPMDs were exposed to PCB- contaminated groundwater in a...
Authors
J.C. Meadows, K. R. Echols, J.N. Huckins, F.A. Borsuk, R.F. Carline, D. E. Tillitt
Aryl hydrocarbon receptor function in early vertebrates:Inducibility of cytochrome P450 1A in agnathan and elasmobranch fish Aryl hydrocarbon receptor function in early vertebrates:Inducibility of cytochrome P450 1A in agnathan and elasmobranch fish
The mammalian aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that controls the expression of cytochrome P450 1A (CYP1A) genes in response to halogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The natural ligand and normal physiologic function of this protein are as yet unknown. One approach to understanding AHR function and
Authors
Mark E. Hahn, Bruce R. Woodin, John J. Stegeman, Donald E. Tillitt
Loading capacity and chromatographic behavior of a porous graphitic carbon column for polychlorinated biphenyls Loading capacity and chromatographic behavior of a porous graphitic carbon column for polychlorinated biphenyls
A porous graphitic carbon column (Hypercarb) was used for the fractionation of polychlorinated biphenyls (PCBs) into classes of 2-4 ortho chlorines, 1 ortho chlorine and 0 ortho chlorine congeners. A method was developed that combined the fractionation of PCBs, polychlorinated dibenzo-p-dioxins and dibenzofurans in a variety of biotic environmental samples. Many of these samples have...
Authors
K. R. Echols, R.W. Gale, K. Feltz, J. O'Laughlin, D. E. Tillitt, T.R. Schwartz
Effects of 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), or an extract derived from field-collected cormorant eggs injected into double-crested cormorant (Phalacrocorax auritus) eggs Effects of 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), or an extract derived from field-collected cormorant eggs injected into double-crested cormorant (Phalacrocorax auritus) eggs
Double-crested cormorant (Phalacrocorax auritus) eggs were injected with either 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), or an extract derived from field-collected double-crested cormorant eggs. These compounds were injected into the yolks of cormorant eggs from an isolated colony on Lake Winnipegosis, Manitoba, Canada. Upon hatching, chicks...
Authors
Debra C. Powell, Richard J. Aulerich, John C. Meadows, Donald E. Tillitt, Jon F. Powell, Janelle C. Restum, Kenneth L. Stromborg, John P. Giesy, Steven J. Bursian
Science and Products
Filter Total Items: 215
Correlation of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced apoptotic cell death in the embryonic vasculature with embryotoxicity Correlation of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced apoptotic cell death in the embryonic vasculature with embryotoxicity
Vertebrate embryos are particularly sensitive to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Identification of tissues that are susceptible to the adverse effects of TCDD is requisite for understanding the embryo toxic effects of TCDD. The objective of the present study was to quantitate the temporal appearance of and dose dependence of apoptosis in TCDD-exposed medaka embryos (Oryzias...
Authors
Susannah M. Cantrell, Jennifer Joy-Schlezinger, John J. Stegeman, Donald E. Tillitt, Mark D. Hannington
Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife
An expert meeting was organized by the World Health Organization (WHO) and held in Stockholm on 15-18 June 1997. The objective of this meeting was to derive consensus toxic equivalency factors (TEFs) for polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) and dioxinlike polychlorinated biphenyls (PCBs) for both human, fish, and wildlife risk assessment. Based on existing...
Authors
M. Van den Berg, L. Birnbaum, A. T. C. Bosveld, B. Brunstrom, P. Cook, M. Feeley, J. P. Giesy, A. Hanberg, R. Hasegawa, S. W. Kennedy, T. Kubiak, J. C. Larsen, F. X. R. Van Leeuwen, A. K. D. Liem, C. Nolt, R. E. Peterson, L. Poellinger, S. Safe, D. Schrenk, Donald E. Tillitt, M. Tysklind, M. Younes, F. Waern, T. Zacharewski
Estimation of uptake rate constants for PCB congeners accumulated by semipermeable membrane devices and brown treat (Salmo trutta) Estimation of uptake rate constants for PCB congeners accumulated by semipermeable membrane devices and brown treat (Salmo trutta)
The triolein-filled semipermeable membrane device (SPMD) is a simple and effective method of assessing the presence of waterborne hydrophobic chemicals. Uptake rate constants for individual chemicals are needed to accurately relate the amounts of chemicals accumulated by the SPMD to dissolved water concentrations. Brown trout and SPMDs were exposed to PCB- contaminated groundwater in a...
Authors
J.C. Meadows, K. R. Echols, J.N. Huckins, F.A. Borsuk, R.F. Carline, D. E. Tillitt
Aryl hydrocarbon receptor function in early vertebrates:Inducibility of cytochrome P450 1A in agnathan and elasmobranch fish Aryl hydrocarbon receptor function in early vertebrates:Inducibility of cytochrome P450 1A in agnathan and elasmobranch fish
The mammalian aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that controls the expression of cytochrome P450 1A (CYP1A) genes in response to halogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The natural ligand and normal physiologic function of this protein are as yet unknown. One approach to understanding AHR function and
Authors
Mark E. Hahn, Bruce R. Woodin, John J. Stegeman, Donald E. Tillitt
Loading capacity and chromatographic behavior of a porous graphitic carbon column for polychlorinated biphenyls Loading capacity and chromatographic behavior of a porous graphitic carbon column for polychlorinated biphenyls
A porous graphitic carbon column (Hypercarb) was used for the fractionation of polychlorinated biphenyls (PCBs) into classes of 2-4 ortho chlorines, 1 ortho chlorine and 0 ortho chlorine congeners. A method was developed that combined the fractionation of PCBs, polychlorinated dibenzo-p-dioxins and dibenzofurans in a variety of biotic environmental samples. Many of these samples have...
Authors
K. R. Echols, R.W. Gale, K. Feltz, J. O'Laughlin, D. E. Tillitt, T.R. Schwartz
Effects of 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), or an extract derived from field-collected cormorant eggs injected into double-crested cormorant (Phalacrocorax auritus) eggs Effects of 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), or an extract derived from field-collected cormorant eggs injected into double-crested cormorant (Phalacrocorax auritus) eggs
Double-crested cormorant (Phalacrocorax auritus) eggs were injected with either 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), or an extract derived from field-collected double-crested cormorant eggs. These compounds were injected into the yolks of cormorant eggs from an isolated colony on Lake Winnipegosis, Manitoba, Canada. Upon hatching, chicks...
Authors
Debra C. Powell, Richard J. Aulerich, John C. Meadows, Donald E. Tillitt, Jon F. Powell, Janelle C. Restum, Kenneth L. Stromborg, John P. Giesy, Steven J. Bursian
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