Donald Tillitt, PhD (Former Employee)
Science and Products
Filter Total Items: 215
The use of semipermeable membrane devices (SPMDs) to concentrate inducers of fish hepatic mixed function oxygenase (MFO): Chapter 12 The use of semipermeable membrane devices (SPMDs) to concentrate inducers of fish hepatic mixed function oxygenase (MFO): Chapter 12
Semipermeable membrane devices (SPMDs) are sampling and concentrating devices comprised of a thin polyethylene membrane containing a small quantity of triolein. They have previously been used to sample air, water and sediments and have concentrated fish tainting compounds from pulp mill effluents. The ability to induce mixed function oxygenases (MFOs) is a property of a variety of...
Authors
Joanne L. Parrott, Donald E. Tillitt
Polychlorinated dibenzo-p-dioxins, dibenzofurans, biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents in fishes from Saginaw Bay, Michigan Polychlorinated dibenzo-p-dioxins, dibenzofurans, biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents in fishes from Saginaw Bay, Michigan
Concentrations of polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), polychlorinated naphthalenes (PCNs), polychlorinated dibenzothiophenes (PCDTs), and 2,3,7,8-tetrachlo-rodibenzo-p-dioxin (2,3,7,8-TCDD) equivalents were measured in composite samples of forage fishes and several sizes of walleyes (Stizostedion vitreum) and...
Authors
John P. Giesy, David J. Jude, Donald E. Tillitt, Robert W. Gale, John C. Meadows, James L. Zajieck, Paul H. Peterman, David A. Verbrugge, J. Thomas Sanderson, Ted R. Schwartz, Marc L. Tuchman
Organochlorine contaminants in double-crested cormorants from Green Bay, Wisconsin: II. Effects of an extract derived from cormorant eggs on the chicken embryo Organochlorine contaminants in double-crested cormorants from Green Bay, Wisconsin: II. Effects of an extract derived from cormorant eggs on the chicken embryo
White Leghorn chicken (Gallus domesticus) eggs were injected prior to incubation with one of four concentrations (0.001, 0.01, 0.1, and 1.0 egg-equivalent) of an extract derived from 1,000 double-crested cormorant (Phalacrocorax auritus) eggs collected at Spider Island adjacent to Green Bay in Lake Michigan. One egg-equivalent corresponded to the concentration of contaminants present in...
Authors
D.C. Powell, R.J. Aulerich, J.C. Meadows, D. E. Tillitt, K. L. Stromborg, T.J. Kubiak, J. P. Giesy, S.J. Bursian
Carrier effects of dosing the h4iie cells with 3,3′,4,4tt´etrachlorobiphenyl (PCB77) in dimethyl sulfoxide or isooctane Carrier effects of dosing the h4iie cells with 3,3′,4,4tt´etrachlorobiphenyl (PCB77) in dimethyl sulfoxide or isooctane
A rat hepatoma cell line, H4IIE serves as a bioassay tool to assess the potential toxicity of dioxin-like chemicals, including polychlorinated biphenyls (PCB) in environmental samples. PCB exposure to these cells induces cytochrome (CYP) P4501A1 activity in a dose-dependent fashion, thus allowing assessment of mixtures. The objective of this study was to determine the effect of different...
Authors
Kyung O. Yu, Jeff W. Fisher, G. Allen Burton, Donald E. Tillitt
An automated HPLC method for the fractionation of polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins, and polychlorinated dibenzofurans in fish tissue on a porous graphitic carbon column An automated HPLC method for the fractionation of polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins, and polychlorinated dibenzofurans in fish tissue on a porous graphitic carbon column
The Ah (aryl-hydrocarbon) hydroxylase-receptor active polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) were fractionated by an automated high-performance liquid chromatography (HPLC) system using the Hypercarb™ porous graphitic carbon (PGC) column. This commercially available column was used to fractionate the di-, mono...
Authors
Kathy R. Echols, Robert W. Gale, Donald E. Tillitt, Ted R. Schwartz, Jerome O’Laughlin
In vivo/in vitro comparison of pharmacokinetics and pharmacodynamics of 3,3',4,4'-tetrachlorobiphenyl (PCB77) In vivo/in vitro comparison of pharmacokinetics and pharmacodynamics of 3,3',4,4'-tetrachlorobiphenyl (PCB77)
The rat hepatoma cell line, H4IIE, serves as a useful tool to assess potential biological effects such as induction of cytochrome P4501A1 expression. The objectives of this study were twofold: to investigate the kinetic time course and dosimetry of PCB77 in rat hepatoma cells dosed with PCB77 and in liver of rats given ip doses of PCB77, and to comparein vitroandin vivoP4501A1 enzyme...
Authors
Kyung O. Yu, Donald E. Tillitt, Janusz Z. Byczkowski, G. Allen Burton, Stephen R. Channel, Joanne M. Drerup, Carlyle D. Flemming, Jeffrey W. Fisher
Science and Products
Filter Total Items: 215
The use of semipermeable membrane devices (SPMDs) to concentrate inducers of fish hepatic mixed function oxygenase (MFO): Chapter 12 The use of semipermeable membrane devices (SPMDs) to concentrate inducers of fish hepatic mixed function oxygenase (MFO): Chapter 12
Semipermeable membrane devices (SPMDs) are sampling and concentrating devices comprised of a thin polyethylene membrane containing a small quantity of triolein. They have previously been used to sample air, water and sediments and have concentrated fish tainting compounds from pulp mill effluents. The ability to induce mixed function oxygenases (MFOs) is a property of a variety of...
Authors
Joanne L. Parrott, Donald E. Tillitt
Polychlorinated dibenzo-p-dioxins, dibenzofurans, biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents in fishes from Saginaw Bay, Michigan Polychlorinated dibenzo-p-dioxins, dibenzofurans, biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents in fishes from Saginaw Bay, Michigan
Concentrations of polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), polychlorinated naphthalenes (PCNs), polychlorinated dibenzothiophenes (PCDTs), and 2,3,7,8-tetrachlo-rodibenzo-p-dioxin (2,3,7,8-TCDD) equivalents were measured in composite samples of forage fishes and several sizes of walleyes (Stizostedion vitreum) and...
Authors
John P. Giesy, David J. Jude, Donald E. Tillitt, Robert W. Gale, John C. Meadows, James L. Zajieck, Paul H. Peterman, David A. Verbrugge, J. Thomas Sanderson, Ted R. Schwartz, Marc L. Tuchman
Organochlorine contaminants in double-crested cormorants from Green Bay, Wisconsin: II. Effects of an extract derived from cormorant eggs on the chicken embryo Organochlorine contaminants in double-crested cormorants from Green Bay, Wisconsin: II. Effects of an extract derived from cormorant eggs on the chicken embryo
White Leghorn chicken (Gallus domesticus) eggs were injected prior to incubation with one of four concentrations (0.001, 0.01, 0.1, and 1.0 egg-equivalent) of an extract derived from 1,000 double-crested cormorant (Phalacrocorax auritus) eggs collected at Spider Island adjacent to Green Bay in Lake Michigan. One egg-equivalent corresponded to the concentration of contaminants present in...
Authors
D.C. Powell, R.J. Aulerich, J.C. Meadows, D. E. Tillitt, K. L. Stromborg, T.J. Kubiak, J. P. Giesy, S.J. Bursian
Carrier effects of dosing the h4iie cells with 3,3′,4,4tt´etrachlorobiphenyl (PCB77) in dimethyl sulfoxide or isooctane Carrier effects of dosing the h4iie cells with 3,3′,4,4tt´etrachlorobiphenyl (PCB77) in dimethyl sulfoxide or isooctane
A rat hepatoma cell line, H4IIE serves as a bioassay tool to assess the potential toxicity of dioxin-like chemicals, including polychlorinated biphenyls (PCB) in environmental samples. PCB exposure to these cells induces cytochrome (CYP) P4501A1 activity in a dose-dependent fashion, thus allowing assessment of mixtures. The objective of this study was to determine the effect of different...
Authors
Kyung O. Yu, Jeff W. Fisher, G. Allen Burton, Donald E. Tillitt
An automated HPLC method for the fractionation of polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins, and polychlorinated dibenzofurans in fish tissue on a porous graphitic carbon column An automated HPLC method for the fractionation of polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins, and polychlorinated dibenzofurans in fish tissue on a porous graphitic carbon column
The Ah (aryl-hydrocarbon) hydroxylase-receptor active polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) were fractionated by an automated high-performance liquid chromatography (HPLC) system using the Hypercarb™ porous graphitic carbon (PGC) column. This commercially available column was used to fractionate the di-, mono...
Authors
Kathy R. Echols, Robert W. Gale, Donald E. Tillitt, Ted R. Schwartz, Jerome O’Laughlin
In vivo/in vitro comparison of pharmacokinetics and pharmacodynamics of 3,3',4,4'-tetrachlorobiphenyl (PCB77) In vivo/in vitro comparison of pharmacokinetics and pharmacodynamics of 3,3',4,4'-tetrachlorobiphenyl (PCB77)
The rat hepatoma cell line, H4IIE, serves as a useful tool to assess potential biological effects such as induction of cytochrome P4501A1 expression. The objectives of this study were twofold: to investigate the kinetic time course and dosimetry of PCB77 in rat hepatoma cells dosed with PCB77 and in liver of rats given ip doses of PCB77, and to comparein vitroandin vivoP4501A1 enzyme...
Authors
Kyung O. Yu, Donald E. Tillitt, Janusz Z. Byczkowski, G. Allen Burton, Stephen R. Channel, Joanne M. Drerup, Carlyle D. Flemming, Jeffrey W. Fisher
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