Tonie Rocke
Tonie Rocke is a Research Epidemiologist at the National Wildlife Health Center.
Science and Products
Filter Total Items: 16
Impact of the oral Sylvatic Plague Vaccine on Non-target Small Rodents: Data Impact of the oral Sylvatic Plague Vaccine on Non-target Small Rodents: Data
In 2013, a large blinded, paired placebo-controlled field trial for the prairie dog oral sylvatic plague vaccine started in the Western US. On 17 paired plots, vaccine and placebo plots, small rodents were trapped annually for 3-5 consecutive nights (when weather allowed). Up on capture, we documented the trap numbers and the processed animals. We noted standard biological information...
SPV field trials bait uptake data SPV field trials bait uptake data
These data were collected as part of a field trial to test the effectiveness of a sylvatic plague vaccine (see Rocke et al., 2017 for details). Vaccine and control plots were selected randomly from the available pairs at each location. Baits containing Rhodamine B, a biomarker, were distributed at each plot. At least 1 week and no more than 2 months post-baiting each year, local...
Monkeypox challenge of rope squirrels: data Monkeypox challenge of rope squirrels: data
Monkeypox virus (MPXV) is a zoonotic disease endemic in Central and West Africa and is the most virulent orthopoxvirus affecting humans since the eradication of variola virus (VARV). In order to assess their reservoir potential, wild-caught rope squirrels were experimentally infected via intranasal and intradermal exposure with a recombinant MPXV strain from Central Africa engineered to...
Field efficacy trials with sylvatic plague vaccine Field efficacy trials with sylvatic plague vaccine
These data were collected as part of a field trial to test the efficacy of a sylvatic plague vaccine. Treatment and control sites were selected randomly from the available sites at each location. Site pairs were a minimum of 20 acres, (with a few exceptions). Prairie dog trapping took place a minimum of two weeks post-baiting and trapping procedures were approved by the NWHC Animal Care...
Filter Total Items: 139
Managing an ongoing threat: Bats and white-nose syndrome Managing an ongoing threat: Bats and white-nose syndrome
No abstract available.
Authors
Tricia Lynn Fry, Amy Haeseler, Anne Ballmann, Tonie E. Rocke
Management of vampire bats and rabies: Past, present, and future Management of vampire bats and rabies: Past, present, and future
Rabies virus transmitted via the bite of common vampire bats (Desmodus rotundus) has surpassed canine-associated cases as the predominant cause of human rabies in Latin America. Cattle, the preferred prey of D. rotundus, suffer extensive mortality from vampire bat associated rabies, with annual financial losses estimated in the tens of millions of dollars. Organized attempts to manage or...
Authors
Tonie E. Rocke, Daniel G. Streicker, Ariel Elizabeth Leon
Monkeypox virus in animals: Current knowledge of viral transmission and pathogenesis in wild animal reservoirs and captive animal models Monkeypox virus in animals: Current knowledge of viral transmission and pathogenesis in wild animal reservoirs and captive animal models
Mpox, formerly called monkeypox, is now the most serious orthopoxvirus (OPXV) infection in humans. This zoonotic disease has been gradually re-emerging in humans with an increasing frequency of cases found in endemic areas, as well as an escalating frequency and size of epidemics outside of endemic areas in Africa. Currently, the largest known mpox epidemic is spreading throughout the...
Authors
Elizabeth Falendysz, Juan G. Lopera, Tonie E. Rocke, Jorge E. Osorio
Sex-biased infections scale to population impacts for an emerging wildlife disease Sex-biased infections scale to population impacts for an emerging wildlife disease
Demographic factors are fundamental in shaping infectious disease dynamics. Aspects of populations that create structure, like age and sex, can affect patterns of transmission, infection intensity and population outcomes. However, studies rarely link these processes from individual to population-scale effects. Moreover, the mechanisms underlying demographic differences in disease are...
Authors
Macy J. Kailing, Joseph R. Hoyt, J. Paul White, Heather M. Kaarakka, Jennifer A. Redell, Ariel Elizabeth Leon, Tonie E. Rocke, John E. DePue, William H. Scullon, Katy L. Parise, Jeffrey T. Foster, A. Marm Kilpatrick, Kate E. Langwig
Experimental infection of Mexican free-tailed bats (Tadarida brasiliensis) with SARS-CoV-2 Experimental infection of Mexican free-tailed bats (Tadarida brasiliensis) with SARS-CoV-2
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus is thought to have originated in wild bats from Asia, and as the resulting pandemic continues into its third year, concerns have been raised that the virus will expand its host range and infect North American wildlife species, including bats. Mexican free-tailed bats (Tadarida brasiliensis) live in large colonies in...
Authors
Jeffrey S. Hall, Erik K. Hofmeister, Hon S. Ip, Sean Nashold, Ariel Elizabeth Leon, Carly Marie Malave, Elizabeth Falendysz, Tonie E. Rocke, M. Carossino, U. Balasuriya, Susan Knowles
Plague and distemper: Threats to black-footed ferret conservation Plague and distemper: Threats to black-footed ferret conservation
No abstract available.
Authors
Tonie E. Rocke
Immunogenicity, safety, and anti-viral efficacy of a subunit SARS-CoV-2 vaccine candidate in captive black-footed ferrets (Mustela nigripes) and their susceptibility to viral challenge Immunogenicity, safety, and anti-viral efficacy of a subunit SARS-CoV-2 vaccine candidate in captive black-footed ferrets (Mustela nigripes) and their susceptibility to viral challenge
A preliminary vaccination trial against the emergent pathogen, SARS-CoV-2, was completed in captive black-footed ferrets (Mustela nigripes; BFF) to assess safety, immunogenicity, and anti-viral efficacy. Vaccination and boosting of 15 BFF with purified SARS-CoV-2 S1 subunit protein produced a nearly 150-fold increase in mean antibody titers compared to pre-vaccination titers. Serum...
Authors
Ariel Elizabeth Leon, Della Garelle, Airn E. Hartwig, Elizabeth Falendysz, Hon S. Ip, Julia S. Lankton, Tyler Tretten, Terry Spraker, Richard A. Bowen, Tonie E. Rocke
Potential effects of environmental conditions on prairie dog flea development and implications for sylvatic plague epizootics Potential effects of environmental conditions on prairie dog flea development and implications for sylvatic plague epizootics
Fleas are common ectoparasites of vertebrates worldwide and vectors of many pathogens causing disease, such as sylvatic plague in prairie dog colonies. Development of fleas is regulated by environmental conditions, especially temperature and relative humidity. Development rates are typically slower at low temperatures and faster at high temperatures, which are bounded by lower and upper...
Authors
Michael D. Samuel, Julia E. Poje, Tonie E. Rocke, Marco E. Metzger
Social effects of rabies infection in male vampire bats (Desmodus rotundus) Social effects of rabies infection in male vampire bats (Desmodus rotundus)
Rabies virus (RABV) transmitted by the common vampire bat (Desmodus rotundus) poses a threat to agricultural development and public health throughout the Neotropics. The ecology and evolution of rabies host-pathogen dynamics are influenced by two infection-induced behavioral changes. RABV-infected hosts often exhibit increased aggression which facilitates transmission, and rabies also...
Authors
Elsa M. Cárdenas-Canales, Sebastian Stockmaier, Eleanor Cronin, Tonie E. Rocke, Jorge E. Osorio, Gerald G. Carter
A recombinant rabies vaccine that prevents viral shedding in rabid common vampire bats (Desmodus rotundus) A recombinant rabies vaccine that prevents viral shedding in rabid common vampire bats (Desmodus rotundus)
Vampire bat transmitted rabies (VBR) is a continuing burden to public health and agricultural sectors in Latin America, despite decades-long efforts to control the disease by culling bat populations. Culling has been shown to disperse bats, leading to an increased spread of rabies. Thus, non-lethal strategies to control VBR, such as vaccination, are desired. Here, we evaluated the safety...
Authors
Elsa M. Cardenas-Canales, Andres Velasco-Villa, James A. Ellison, Panayampalli S. Satheshkumar, Jorge E. Osario, Tonie E. Rocke
Impact of molecular modifications on the Immunogenicity and efficacy of recombinant raccoon poxvirus-vectored rabies vaccine candidates in mice Impact of molecular modifications on the Immunogenicity and efficacy of recombinant raccoon poxvirus-vectored rabies vaccine candidates in mice
Rabies is an ancient disease that is responsible for approximately 59,000 human deaths annually. Bats (Order Chiroptera) are thought to be the original hosts of rabies virus (RABV) and currently account for most rabies cases in wildlife in the Americas. Vaccination is being used to manage rabies in other wildlife reservoirs like fox and raccoon, but no rabies vaccine is available for...
Authors
Carly Marie Malave, Jaime Lopera-Madrid, Lex Guillermo Medina-Magues, Tonie E. Rocke, Jorge E. Osorio
Enzootic plague reduces survival of Mexican woodrats (Neotoma mexicana) in Colorado Enzootic plague reduces survival of Mexican woodrats (Neotoma mexicana) in Colorado
Plague is a flea-vectored disease introduced to North America c. 1900. It is lethal to many American mammal species, causes major die-offs (epizootics) in some populations, and may be ecologically disruptive even at lower interepizootic (enzootic) levels of transmission. We sought to determine the effects of enzootic plague on survival of Mexican woodrats (Neotoma mexicana) and to test...
Authors
Dean E. Biggins, Shantini Ramakrishnan, Tonie E. Rocke, Judy L. Williamson, Jeffrey Wimsatt
Science and Products
Filter Total Items: 16
Impact of the oral Sylvatic Plague Vaccine on Non-target Small Rodents: Data Impact of the oral Sylvatic Plague Vaccine on Non-target Small Rodents: Data
In 2013, a large blinded, paired placebo-controlled field trial for the prairie dog oral sylvatic plague vaccine started in the Western US. On 17 paired plots, vaccine and placebo plots, small rodents were trapped annually for 3-5 consecutive nights (when weather allowed). Up on capture, we documented the trap numbers and the processed animals. We noted standard biological information...
SPV field trials bait uptake data SPV field trials bait uptake data
These data were collected as part of a field trial to test the effectiveness of a sylvatic plague vaccine (see Rocke et al., 2017 for details). Vaccine and control plots were selected randomly from the available pairs at each location. Baits containing Rhodamine B, a biomarker, were distributed at each plot. At least 1 week and no more than 2 months post-baiting each year, local...
Monkeypox challenge of rope squirrels: data Monkeypox challenge of rope squirrels: data
Monkeypox virus (MPXV) is a zoonotic disease endemic in Central and West Africa and is the most virulent orthopoxvirus affecting humans since the eradication of variola virus (VARV). In order to assess their reservoir potential, wild-caught rope squirrels were experimentally infected via intranasal and intradermal exposure with a recombinant MPXV strain from Central Africa engineered to...
Field efficacy trials with sylvatic plague vaccine Field efficacy trials with sylvatic plague vaccine
These data were collected as part of a field trial to test the efficacy of a sylvatic plague vaccine. Treatment and control sites were selected randomly from the available sites at each location. Site pairs were a minimum of 20 acres, (with a few exceptions). Prairie dog trapping took place a minimum of two weeks post-baiting and trapping procedures were approved by the NWHC Animal Care...
Filter Total Items: 139
Managing an ongoing threat: Bats and white-nose syndrome Managing an ongoing threat: Bats and white-nose syndrome
No abstract available.
Authors
Tricia Lynn Fry, Amy Haeseler, Anne Ballmann, Tonie E. Rocke
Management of vampire bats and rabies: Past, present, and future Management of vampire bats and rabies: Past, present, and future
Rabies virus transmitted via the bite of common vampire bats (Desmodus rotundus) has surpassed canine-associated cases as the predominant cause of human rabies in Latin America. Cattle, the preferred prey of D. rotundus, suffer extensive mortality from vampire bat associated rabies, with annual financial losses estimated in the tens of millions of dollars. Organized attempts to manage or...
Authors
Tonie E. Rocke, Daniel G. Streicker, Ariel Elizabeth Leon
Monkeypox virus in animals: Current knowledge of viral transmission and pathogenesis in wild animal reservoirs and captive animal models Monkeypox virus in animals: Current knowledge of viral transmission and pathogenesis in wild animal reservoirs and captive animal models
Mpox, formerly called monkeypox, is now the most serious orthopoxvirus (OPXV) infection in humans. This zoonotic disease has been gradually re-emerging in humans with an increasing frequency of cases found in endemic areas, as well as an escalating frequency and size of epidemics outside of endemic areas in Africa. Currently, the largest known mpox epidemic is spreading throughout the...
Authors
Elizabeth Falendysz, Juan G. Lopera, Tonie E. Rocke, Jorge E. Osorio
Sex-biased infections scale to population impacts for an emerging wildlife disease Sex-biased infections scale to population impacts for an emerging wildlife disease
Demographic factors are fundamental in shaping infectious disease dynamics. Aspects of populations that create structure, like age and sex, can affect patterns of transmission, infection intensity and population outcomes. However, studies rarely link these processes from individual to population-scale effects. Moreover, the mechanisms underlying demographic differences in disease are...
Authors
Macy J. Kailing, Joseph R. Hoyt, J. Paul White, Heather M. Kaarakka, Jennifer A. Redell, Ariel Elizabeth Leon, Tonie E. Rocke, John E. DePue, William H. Scullon, Katy L. Parise, Jeffrey T. Foster, A. Marm Kilpatrick, Kate E. Langwig
Experimental infection of Mexican free-tailed bats (Tadarida brasiliensis) with SARS-CoV-2 Experimental infection of Mexican free-tailed bats (Tadarida brasiliensis) with SARS-CoV-2
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus is thought to have originated in wild bats from Asia, and as the resulting pandemic continues into its third year, concerns have been raised that the virus will expand its host range and infect North American wildlife species, including bats. Mexican free-tailed bats (Tadarida brasiliensis) live in large colonies in...
Authors
Jeffrey S. Hall, Erik K. Hofmeister, Hon S. Ip, Sean Nashold, Ariel Elizabeth Leon, Carly Marie Malave, Elizabeth Falendysz, Tonie E. Rocke, M. Carossino, U. Balasuriya, Susan Knowles
Plague and distemper: Threats to black-footed ferret conservation Plague and distemper: Threats to black-footed ferret conservation
No abstract available.
Authors
Tonie E. Rocke
Immunogenicity, safety, and anti-viral efficacy of a subunit SARS-CoV-2 vaccine candidate in captive black-footed ferrets (Mustela nigripes) and their susceptibility to viral challenge Immunogenicity, safety, and anti-viral efficacy of a subunit SARS-CoV-2 vaccine candidate in captive black-footed ferrets (Mustela nigripes) and their susceptibility to viral challenge
A preliminary vaccination trial against the emergent pathogen, SARS-CoV-2, was completed in captive black-footed ferrets (Mustela nigripes; BFF) to assess safety, immunogenicity, and anti-viral efficacy. Vaccination and boosting of 15 BFF with purified SARS-CoV-2 S1 subunit protein produced a nearly 150-fold increase in mean antibody titers compared to pre-vaccination titers. Serum...
Authors
Ariel Elizabeth Leon, Della Garelle, Airn E. Hartwig, Elizabeth Falendysz, Hon S. Ip, Julia S. Lankton, Tyler Tretten, Terry Spraker, Richard A. Bowen, Tonie E. Rocke
Potential effects of environmental conditions on prairie dog flea development and implications for sylvatic plague epizootics Potential effects of environmental conditions on prairie dog flea development and implications for sylvatic plague epizootics
Fleas are common ectoparasites of vertebrates worldwide and vectors of many pathogens causing disease, such as sylvatic plague in prairie dog colonies. Development of fleas is regulated by environmental conditions, especially temperature and relative humidity. Development rates are typically slower at low temperatures and faster at high temperatures, which are bounded by lower and upper...
Authors
Michael D. Samuel, Julia E. Poje, Tonie E. Rocke, Marco E. Metzger
Social effects of rabies infection in male vampire bats (Desmodus rotundus) Social effects of rabies infection in male vampire bats (Desmodus rotundus)
Rabies virus (RABV) transmitted by the common vampire bat (Desmodus rotundus) poses a threat to agricultural development and public health throughout the Neotropics. The ecology and evolution of rabies host-pathogen dynamics are influenced by two infection-induced behavioral changes. RABV-infected hosts often exhibit increased aggression which facilitates transmission, and rabies also...
Authors
Elsa M. Cárdenas-Canales, Sebastian Stockmaier, Eleanor Cronin, Tonie E. Rocke, Jorge E. Osorio, Gerald G. Carter
A recombinant rabies vaccine that prevents viral shedding in rabid common vampire bats (Desmodus rotundus) A recombinant rabies vaccine that prevents viral shedding in rabid common vampire bats (Desmodus rotundus)
Vampire bat transmitted rabies (VBR) is a continuing burden to public health and agricultural sectors in Latin America, despite decades-long efforts to control the disease by culling bat populations. Culling has been shown to disperse bats, leading to an increased spread of rabies. Thus, non-lethal strategies to control VBR, such as vaccination, are desired. Here, we evaluated the safety...
Authors
Elsa M. Cardenas-Canales, Andres Velasco-Villa, James A. Ellison, Panayampalli S. Satheshkumar, Jorge E. Osario, Tonie E. Rocke
Impact of molecular modifications on the Immunogenicity and efficacy of recombinant raccoon poxvirus-vectored rabies vaccine candidates in mice Impact of molecular modifications on the Immunogenicity and efficacy of recombinant raccoon poxvirus-vectored rabies vaccine candidates in mice
Rabies is an ancient disease that is responsible for approximately 59,000 human deaths annually. Bats (Order Chiroptera) are thought to be the original hosts of rabies virus (RABV) and currently account for most rabies cases in wildlife in the Americas. Vaccination is being used to manage rabies in other wildlife reservoirs like fox and raccoon, but no rabies vaccine is available for...
Authors
Carly Marie Malave, Jaime Lopera-Madrid, Lex Guillermo Medina-Magues, Tonie E. Rocke, Jorge E. Osorio
Enzootic plague reduces survival of Mexican woodrats (Neotoma mexicana) in Colorado Enzootic plague reduces survival of Mexican woodrats (Neotoma mexicana) in Colorado
Plague is a flea-vectored disease introduced to North America c. 1900. It is lethal to many American mammal species, causes major die-offs (epizootics) in some populations, and may be ecologically disruptive even at lower interepizootic (enzootic) levels of transmission. We sought to determine the effects of enzootic plague on survival of Mexican woodrats (Neotoma mexicana) and to test...
Authors
Dean E. Biggins, Shantini Ramakrishnan, Tonie E. Rocke, Judy L. Williamson, Jeffrey Wimsatt